نتایج جستجو برای: hypoxia inducible factors

تعداد نتایج: 1159240  

2015
Takaoki Furukawa Yoshihiro Miyata Kei Kushitani Takahiro Mimae Yasuhiro Tsutani Yukio Takeshima Morihito Okada

OBJECTIVE High maximum standardized uptake values on [(18)F]-fluoro-2-deoxyglucose positron emission tomography are associated with inferior survival in non-small cell lung cancer. Here, we investigated the biological mechanisms underlying [(18)F]-fluoro-2-deoxyglucose uptake in non-small cell lung cancer. METHODS This study included 133 patients with non-small cell lung cancer (109 with aden...

Journal: :Blood 2013
Chunzhang Yang Michael G Sun Joey Matro Thanh T Huynh Shervin Rahimpour Josef T Prchal Ronald Lechan Russell Lonser Karel Pacak Zhengping Zhuang

Hypoxia-inducible factors (HIFs) control the cellular response to hypoxia and, when dysregulated, contribute to tumorigenesis. Previously, we identified 2 gain-of-function somatic mutations in patients presenting with multiple paragangliomas or somatostatinomas, and polycythemia. Here, we report 2 additional unique HIF2A mutations, which disrupt the hydroxylation domain recognized by prolyl hyd...

ژورنال: بوم شناسی آبزیان 2015
Kolangi Miandare, Hamed , Akbarzadeh, Arash , Jafari, Omid ,

In the present study, the levels of the hypoxia-inducible factors (hif-1, hif-2) transcripts were evaluated during development of an ancient fish species, Beluga sturgeon (Huso huso) in a normal oxygen environment. The transcripts of hif-1, hif-2 were detected in all developmental time-points of H. huso from embryos to juvenile fish. Changes in normalized hif-1, hif-2 mRNA expression by using t...

2017

Scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) have demonstrated the fundamental role of the hypoxia response in the correct formation of the heart ventricles. Hypoxia, a drop in the levels of oxygen, triggers a complex adaptive response to reestablish the tissue supply of nutrients and oxygen. The key elements of this response are the hypoxia-inducible ...

2014
Kyung Min Park Sharon Gerecht

Oxygen is vital for the existence of all multicellular organisms, acting as a signalling molecule regulating cellular activities. Specifically, hypoxia, which occurs when the partial pressure of oxygen falls below 5%, plays a pivotal role during development, regeneration and cancer. Here we report a novel hypoxia-inducible (HI) hydrogel composed of gelatin and ferulic acid that can form hydroge...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Damayanti Chakraborty M A Karim Rumi Toshihiro Konno Michael J Soares

Natural killer (NK) cells are recruited into the uterine stroma during establishment of the hemochorial placenta and are proposed regulators of uterine spiral artery remodeling. Failures in uterine spiral artery remodeling are linked to diseases of pregnancy. This prompted an investigation of the involvement of NK cells in placentation. NK cell depletion decreased the delivery of proangiogenic ...

2003
Vladimir A. Shatrov Vadim V. Sumbayev Jie Zhou Bernhard Brüne

http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#reprints Information about ordering reprints may be found online at: http://bloodjournal.hematologylibrary.org/site/subscriptions/index.xhtml Information abo...

Journal: :Intisari Sains Medis 2022

Anemia is one of the homeostatic abnormalities caused by chronic kidney disease and also frequently problem encountered in end-stage renal patients, regardless hemodialysis treatment. significantly impairs function, increases morbidity mortality risk, deteriorates quality life. Chronic disease’s patients with anemia conditions are affected numerous factors, including decreased production endoge...

2010
Terhi Jokilehto Panu M Jaakkola

Tumour hypoxia is a well-known microenvironmental factor that causes cancer progression and resistance to cancer treatment. This involves multiple mechanisms of which the best-understood ones are mediated through transcriptional gene activation by the hypoxia-inducible factors (HIFs). HIFs in turn are regulated in response to oxygen availability by a family of iron- and 2-oxoglutarate-dependent...

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