نتایج جستجو برای: hypoxia inducible factors

تعداد نتایج: 1159240  

Journal: :The Journal of clinical investigation 2000
G L Semenza

Journal: :Acta neurobiologiae experimentalis 2011
Ilona Szablowska-Gadomska Valery Zayat Leonora Buzanska

The stem cells are characterized by self-renewal ability and potential to differentiate into other cell types of the body. They are residuing in defined microenvironments - "stem cell niches". The embryonic stem cells (ESC) are derived from embryos which exist in 3-5 percent oxygen condition. This environment is physiologically normal not only for ES cells but also for many other types of stem ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Daniele M Gilkes Lisha Xiang Sun Joo Lee Pallavi Chaturvedi Maimon E Hubbi Denis Wirtz Gregg L Semenza

Overexpression of Rho kinase 1 (ROCK1) and the G protein RhoA is implicated in breast cancer progression, but oncogenic mutations are rare, and the molecular mechanisms that underlie increased ROCK1 and RhoA expression have not been determined. RhoA-bound ROCK1 phosphorylates myosin light chain (MLC), which is required for actin-myosin contractility. RhoA also activates focal adhesion kinase (F...

2014
Angela Yuen Begoña Díaz

Intratumoral hypoxia is a common feature of solid tumors. Recent advances in cancer biology indicate that hypoxia is not only a consequence of unrestrained tumor growth, but also plays an active role in promoting tumor progression, malignancy, and resistance to therapy. Hypoxia signaling is mediated by the hypoxia-inducible factors (HIFs), which are not only stabilized under hypoxia, but also b...

2014
Larissa A. Shimoda Steven S. Laurie

Shimoda LA, Laurie SS. Hif and pulmonary vascular responses to hypoxia. J Appl Physiol 116: 867– 874, 2014. First published December 12, 2013; doi:10.1152/japplphysiol.00643.2013.—In the lung, acute reductions in oxygen lead to hypoxic pulmonary vasoconstriction, whereas prolonged exposures to hypoxia result in sustained vasoconstriction, pulmonary vascular remodeling, and the development of pu...

Journal: :Molecular cancer research : MCR 2014
Johnny A Sena Liyi Wang Matthew R Pawlus Cheng-Jun Hu

UNLABELLED Adrenomedullin (ADM) is important for tumor angiogenesis, tumor cell growth, and survival. Under normoxic conditions, the ADM gene was found to produce two alternative transcripts, a fully spliced transcript that produces AM and PAMP peptides and intron-3-retaining transcript that produces a less functionally significant PAMP peptide only. ADM is a well-established hypoxia inducible ...

Journal: :The Biochemical journal 2004
Clifton Lee Dalgard Huasheng Lu Ahmed Mohyeldin Ajay Verma

Adaptations to change in oxygen availability are crucial for survival of multi-cellular organisms and are also implicated in several disease states. Such adaptations rely upon gene expression regulated by the heterodimeric transcription factors HIFs (hypoxia-inducible factors). Enzymes that link changes in oxygen tensions with the stability and transcriptional activity of HIFs are considered as...

2014
Alison J Harris AA Roger Thompson Moira KB Whyte Sarah R Walmsley

Leukocytes recruited to infected, damaged, or inflamed tissues during an immune response must adapt to oxygen levels much lower than those in the circulation. Hypoxia inducible factors (HIFs) are key mediators of cellular responses to hypoxia and, as in other cell types, HIFs are critical for the upregulation of glycolysis, which enables innate immune cells to produce adenosine triphosphate ana...

Journal: :Nephron Experimental Nephrology 2008

Journal: :Physiology 2010
Cormac T Taylor Jennifer C McElwain

Metazoan diversification occurred during a time when atmospheric oxygen levels fluctuated between 15 and 30%. The hypoxia-inducible factor (HIF) is a primary regulator of the adaptive transcriptional response to hypoxia. Although the HIF pathway is highly conserved, its complexity increased during periods when atmospheric oxygen concentrations were increasing. Thus atmospheric oxygen levels may...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید