Recent behavioural and neural research suggests that awareness is intimately related to top-down cognitive functions such as attention. Here I present a characterization of this relationship, guided by Lavie’s load theory. Load theory proposes that perception has limited capacity but proceeds automatically on all stimuli (whether relevant to the task at hand or not) until capacity is exhausted,...

Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1).  HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division. In this study, we aimed to determine and comp...

BACKGROUND The infectivity of the HIV-1 acute phase has been directly measured only once, from a retrospectively identified cohort of serodiscordant heterosexual couples in Rakai, Uganda. Analyses of this cohort underlie the widespread view that the acute phase is highly infectious, even more so than would be predicted from its elevated viral load, and that transmission occurring shortly after ...

Acute viral infections pose many practical challenges for the accurate assessment of the impact of novel therapies on viral growth and decay. Using the example of influenza A, we illustrate how the measurement of infection-related quantities that determine the dynamics of viral load within the human host, can inform investigators on the course and severity of infection and the efficacy of a nov...

Two fundamental problems in distributed network architecture grid, are Search and optimal timing for detecting the source for proper distribution of requests Scheduling and optimal scheduling is to minimize time and costs. In this paper a new approach to both The process of dividing the dependent and independent processing and load balancing processing is provided. Breastfed of ants algorithm b...

We present a novel holistic approach (called IC – Intra-route and Inter-route Coordination) to prolong the sensor network lifetime under the end-to-end delivery delay constraint. IC is composed of two lifetime balancing modules: (i) the IntraRoute Coordination module that allows the nodes on the same route to balance their nodal lifetimes through adjusting the MAC behaviors collaboratively; (ii...

HIV RNA viral load measures are often subjected to some upper and lower detection limits depending on the quantification assays. Hence, the responses are either left or right censored. Linear (and nonlinear) mixed-effects models (with modifications to accommodate censoring) are routinely used to analyze this type of data and are based on normality assumptions for the random terms. However, thos...

BACKGROUND Routine viral load monitoring of patients on antiretroviral therapy (ART) is not affordable in most resource-limited settings. METHODS A cross-sectional study of 496 Ugandans established on ART was performed at the Infectious Diseases Institute, Kampala, Uganda. Adherence, clinical and laboratory parameters were assessed for their relationship with viral failure by multivariate log...