Abstract Introduction The association between atrial fibrillation (AF) and chronic kidney disease (CKD) is directly proportional carries a higher risk of death, bleeding, thromboembolism (TE). There uncertainty on the clinical benefit direct oral anticoagulants (DOAC) in patients with advanced stages CKD. Purpose To perform systematic review meta-analysis available literature efficacy safety DO...

OBJECTIVES To determine whether perioperative fluid restrictive administration can reduce specific postoperative complications in adults undergoing major abdominal surgery.  Methods: We searched the MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials, Google scholar, and article reference lists (up to December 2015) for studies that assessed fluid therapy and morbidity or mortal...

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BACKGROUND AND OBJECTIVES Some evidence suggests that bisphosphonates may reduce atherosclerosis, while concerns have been raised about atrial fibrillation. We conducted a meta-analysis to determine the effects of bisphosphonates on total adverse cardiovascular (CV) events, atrial fibrillation, myocardial infarction (MI), stroke, and CV death in adults with or at risk for low bone mass. METHO...

Diffusible iodine-based contrast-enhanced computed tomography presents a comparatively new tool kit for imaging fine-scale three-dimensional phenotypes that is rapidly becoming standard anatomical practice. However, relatively few studies have attempted to look at subtle differences in staining protocols or attempted to model tissue reactions to gain insight into staining mechanisms. Here, two ...

The previously unstudied vaccinia virus gene I2L is conserved in all orthopoxviruses. We show here that the 8-kDa I2 protein is expressed at late times of infection, is tightly associated with membranes, and is encapsidated in mature virions. We have generated a recombinant virus in which I2 expression is dependent upon the inclusion of tetracycline in the culture medium. In the absence of I2, ...

Two constructs encoding the human micro-opioid receptor (hMOR) fused at its C terminus to either one of two Galpha subunits, Galpha(o1) (hMOR-Galpha(o1)) and Galpha(i2) (hMOR-Galpha(i2)), were expressed in Escherichia coli at levels suitable for pharmacological studies (0.4-0.5 pmol/mg). Receptors fused to Galpha(o1) or to Galpha(i2) maintained high-affinity binding of the antagonist diprenorph...

Some studies suggested that prediabetes was associated with the risk of pancreatic cancer. However, the results were controversial. Thus, a meta-analysis was conducted to investigate the association between prediabetes and pancreatic cancer risk. PubMed, EMBASE, and Cochrane database were searched. The association was estimated by hazard ratio (HR) with its 95% confidence interval (CI). 12 stud...

UNLABELLED This systematic review looks at the incidence of pressure ulcers in surgical patients of the last 5 years. METHODS The authors searched Pubmed and Web of Science for studies published after 2005. Screen- ing and data abstraction were performed independently by 2 reviewers. RESULTS Seventeen studies (5,451 patients) met the inclusion criteria. The incidence of surgery-related pre...

BACKGROUND Anderson-Fabry disease (AFD) is an X-linked recessive inborn error of glycosphingolipid metabolism caused by a deficiency of alpha-galactosidase A. Renal failure, heart and cerebrovascular involvement reduce survival. A Cochrane review provided little evidence on the use of enzyme replacement therapy (ERT). We now complement this review through a linear regression and a pooled analys...