Infectious bursal disease (IBD), caused by infectious virus (IBDV), is one among the top five diseases of poultry that discernibly affects commercial industry. The mutating viral genome IBDV accounts for outbreaks in fields even after following stringent biosecurity measures and vaccination protocols. present study focussed on characterisation an field virus, IBD/CVAS/6, from a vaccinated flock...

The primary feature of vvIBDV is the ability to induce high mortality. Mortality ranges from 5% – 25% in broilers and 30% – 70% in layers. Surviving birds are severely affected with a high condemnation rate. vvIBDV induces clinical signs similar to Gumboro disease, which is induced by classical virulent strains of IBDV, except that the disease is more pronounced and acute in individual birds an...

This study aimed to investigate the effect of mannose-binding lectin (MBL) on infections with Escherichia coli in chickens. Initially, the basic levels of MBL in 4 different lines of layer chickens, namely ISA Brown, Lohmann Selected Leghorn, Lohmann Braun, and Hellevad, were investigated. This investigation revealed a 2-to 3-fold difference in the basic levels of MBL in serum between some of t...

A reverse genetics system for birnavirus, based on synthetic transcripts of the infectious bursal disease virus (IBDV) genome, was recently developed (E. Mundt and V. N. Vakharia, Proc. Natl. Acad. Sci. USA 93:11131-11136, 1996). To study the function of the 17-kDa nonstructural (NS) protein in viral growth and pathogenesis, we constructed a cDNA clone of IBDV segment A in which the first and o...

A significant protection provided by maternal antibodies against avian adenovirus serotypes 8 and 11, previously associated with the inclusion body hepatitis and hydropericardium syndrome, was observed in breeder progenies after challenge at 1 and 7 days of age. At two weeks of age, in the presence of low maternal antibodies against avian adenovirus (AAV), chicken anemia virus (CAV) and infecti...

Immunosuppression can increase the susceptibility of chickens to other disease-causing pathogens and interfere with efficacy vaccination against those pathogens. Chicken anaemia virus (CAV) infectious bursal disease (IBDV) are common causes immunosuppression in chickens. was induced by experimental infection either CAV or IBDV assess effect on Mycoplasma gallisepticum strain ts-304 virulent M. ...

Infectious bursal disease (IBD) is an economically important viral disease of chickens with worldwide distribution which suppresses the immune system of young chickens. VP2 is the major host-protective protein of infectious bursal disease virus (IBDV). The encoding region of VP2 protein was PCR amplified from a plasmid containing a cDNA fragment of large genomic segment of IBDV, strain D78. Thi...

Infectious bursal disease virus (IBDV) induces apoptosis and immunosuppression. To understand the molecular mechanisms involved in the pathogenesis of infectious bursal disease (IBD) and the host-directed antiviral responses, cDNA microarrays were used to identify the differentially expressed transcripts in IBDV-infected chicken embryonic fibroblasts. The results suggest a general suppression o...

AIM The aim of the present study was to diagnose infectious bursal disease (IBD) using gross, histopathological, and immunopathological approaches and to compare efficacy of immunohistochemical techniques with conventional diagnostic techniques. MATERIALS AND METHODS A total of 33 samples were collected from the six different poultry farms from Ludhiana and the nearby districts. Upon gross an...

Infectious bursal disease (IBD) is an immunosuppressive, acute and highly contagious illness of growing-poultry stock infected with infectious bursal disease virus (IBDV). It is common in Pakistan, causing potential economic losses throughout the year. The objective of the study is to propose a rapid, sensitive and specific diagnostic tool, and compare it with existing commonly used reverse tra...