In a previous work we applied a discrete symmetry (Z ′ 2) in order to light fermions acquire mass only at one loop level. This symmetry and the assumption of alignment between fermions and sfermions allow us to avoid FCNC problems. Here a more general hypothesis of flavor mixing in the sfermion sector of MSSM is considered and we show that the s quark is heavier than u, d quarks due to differen...

BACKGROUND New epithelial cells are generated through the proliferation and differentiation of resident progenitor cells in the nasal cavity. In several upper airway diseases, such as cystic fibrosis and chronic rhinosinusitis, self-renewing progenitor cells may be functionally defective, or compromised in their ability, to regenerate cells that maintain normal mucociliary clearance. Herein, we...

Object Aneurysmal subarachnoid hemorrhage triggers an intense inflammatory response, which is suspected to increase the risk for secondary complications such as delayed cerebral ischemia (DCI). However, to date, the monitoring of the inflammatory response to detect secondary complications such as DCI has not become part of the clinical routine diagnostic. Here, we aim to illustrate the time cou...

OBJECTIVE To examine whether the psychological traits of hopelessness and depressive symptoms are related to endothelial dysfunction. METHODS Data are derived from a subsample of 434 respondents in the 2001 to 2003 Chicago Community Adult Health Study, a population-based survey designed to study the impact of psychological attributes, neighborhood environment, and socioeconomic circumstances ...

Fragments of intercellular adhesion molecule 1 (ICAM- 1) containing only the two most N terminal of its five immunoglobulin SF domains bind to rhinovirus 3 with the same affinity and kinetics as a fragment with the entire extracellular domain. The fully active two-domain fragments contain 5 or 14 more residues than a previously described fragment that is only partially active. Comparison of X-r...

We construct explicit examples with a horizontal, " anomalous " U (1) gauge group, which, in a supersymmetric extension of the standard model, reproduce qualitative features of the fermion spectrum and CKM matrix, and suppress FCNC and proton decay rates without the imposition of global symmetries. We review the motivation for such " more " minimal supersymmetric standard models and their predi...

We construct explicit examples with a horizontal, “anomalous” U(1) gauge group, which, in a supersymmetric extension of the standard model, reproduce qualitative features of the fermion spectrum and CKM matrix, and suppress FCNC and proton decay rates without the imposition of global symmetries. We review the motivation for such “more” minimal supersymmetric standard models and their prediction...

Osteosarcoma (OS) is the most common histological type of primary bone cancer. The present study was designed to identify the key genes and signaling pathways involved in the metastasis of OS. Microarray data of GSE39055 were downloaded from the Gene Expression Omnibus database, which included 19 OS biopsy specimens before metastasis (control group) and 18 OS biopsy specimens after metastasis (...

Blood–brain barrier (BBB) dysfunction is a key hallmark in the pathology of many neuroinflammatory disorders. Extracellular vesicles (EVs) are lipid membrane-enclosed carriers molecular cargo that involved cell-to-cell communication. Circulating endothelial EVs increased plasma patients with neurological disorders, and immune cell-derived known to modulate cerebrovascular functions. However, li...