We investigated the effects of intracerebroventricular (ICV) injection of orexin-A on plasma corticosterone (CORT) concentration and brain monoamine metabolism to clarify the mechanism by which ICV orexin-A induced arousal in chicks. In Experiment 1, plasma CORT concentrations were measured as an indicator of hypothalamic-pituitary-adrenal (HPA) axis activity. There was no significant differenc...

Functional Size Measurement methods –like the COSMIC method– are widely used but have two major shortcomings: they require a complete and detailed knowledge of user requirements and they are carried out via relatively expensive and lengthy processes. To tackle these issues, simplified measurement processes have been proposed that can be applied to requirements specifications even if they are in...

We study the following lot-sizing models that recently appeared in the literature: a lotsizing model with a remanufacturing option, a lot-sizing model with production time windows, and a lot-sizing model with cumulative capacities. We show the equivalence of these models with a classical model: the lot-sizing model with inventory bounds.

This paper reports an empirical study that used computer science major students as experimental subjects to evaluate the productivity and the reproducibility of RmFFP. This is a functional size measurement procedure designed according to the COSMIC-FFP method for object-oriented systems that are specified using the OO-Method approach. The results show that the productivity of RmFFP is acceptabl...

The present study was designed to investigate the role of central adrenoceptors in the hypotensive effect of intracerebroventricular (ICV) injection of norepinephrine (NE) in conscious rabbits. Experiments were carried out on 19 adult rabbits (oryctolagus cuniculus) of either sex. A dose-dependent hypotensive response to ICV injection of NE was observed with no significant change in heart rate....

BACKGROUND This paper summarizes the findings of a long term study addressing the question of how several brain volume measure are related to three major mental illnesses in a Colorado subject group. It reports results obtained from a large N, collected and analyzed by the same laboratory over a multiyear period, with visually guided MRI segmentation being the primary initial analytic tool. M...

retrograde approach is considered technically more challenging, with published failure rates for ileal intubation as high as 30% [1]. The technique for ileal intubation described by Yamamoto et al. involves visualizing the ileocecal valve (ICV) while the overtube balloon is inflated in the ascending colon, followed by pull-back of the balloon to reduce the ileocolic angle (thus exposing the ICV...

Ghrelin, an acylated peptide produced predominantly in the stomach, stimulates feeding and GH secretion via interactions with the GH secretagogue type 1a receptor (GHS-R1a), the functionally active form of the GHS-R. Ghrelin molecules exist in the stomach and hypothalamus as two major endogenous forms, a form acylated at serine 3 (ghrelin) and a des-acylated form (des-acyl ghrelin). Acylation i...