Adaptive resistance to targeted therapy such as BRAF inhibitors represents in melanoma a major drawback to this otherwise powerful treatment. Some of the underlying molecular mechanisms have recently been described: hyperactivation of the BRAF-MAPK pathway, of the AKT pathway, of the TGFβ/EGFR/PDGFRB pathway, or the low MITF/AXL ratio. Nevertheless, the phenomenon of early resistance is still n...

The transcription factor Foxp3 dominantly controls regulatory T (Treg) cell function, and only its continuous expression guarantees the maintenance of full Treg cell-suppressive capacity. However, transcriptional regulators maintaining Foxp3 transcription are incompletely described. Here, we report that high E47 transcription factor activity in Treg cells resulted in unstable Foxp3 expression. ...

The growth of credit card application needs to be balanced with the anticipation of bad credit risk because it does not use security collateral as warranty. The usage of credit scoring can be used to help the credit risk analysis in determining the applicant's eligibility. Data mining has been proven as a valuable tool for credit scoring. The aim of this research is to design a data mining mode...

We consider privacy preserving decision tree induction via ID3 in the case where the training data is horizontally or vertically distributed. Furthermore, we consider the same problem in the case where the data is both horizontally and vertically distributed, a situation we refer to as grid partitioned data. We give an algorithm for privacy preserving ID3 over horizontally partitioned data invo...

Regulatory T cells (Treg cells) that express the transcription factor Foxp3 are instrumental in the induction and maintenance of peripheral immune tolerance and the regulation of tumor immunity and infection1–8. The differentiation of Foxp3+ Treg cells requires transforming growth factor-β (TGF-β) signaling9–13; however, the molecular pathways that transduce this signal remain largely unknown. ...

A complex set of extracellular signals is required for neural crest (NC) specification. However, how these signals function to coordinate cell cycle progression and differentiation remains poorly understood. Here,we report inXenopus a role forStat3 inthis process downstream of FGF signaling. Depletion of Stat3 inhibited NC gene expression and proliferation while its overexpression expanded the ...

Interfacing through the continuously rising amounts of data in technical, medical, scientific, engineering, industrial and monetary fields and their renovation to logical form for the human user is one of the main requirements. To quickly discover and analyze complex patterns and requirements, we need the efficient techniques and need to learn from new data will be necessary for information-int...

OBJECTIVES Recent studies using next-generation sequencing (NGS) analysis disclosed the importance of the intrinsic activation of the B-cell receptor (BCR) pathway in the pathogenesis of sporadic Burkitt lymphoma (sBL) due to mutations of TCF3/ID3 genes. Since no definitive data are available on the genetic landscape of endemic Burkitt (eBL), we first assessed the mutation frequency of TCF3/ID3...

A complex set of extracellular signals is required for neural crest (NC) specification. However, how these signals function to coordinate cell cycle progression and differentiation remains poorly understood. Here,we report inXenopus a role forStat3 inthis process downstream of FGF signaling. Depletion of Stat3 inhibited NC gene expression and proliferation while its overexpression expanded the ...

Precise control of the timing and magnitude of Notch signaling is essential for the normal development of many tissues, but the feedback loops that regulate Notch are poorly understood. Developing T cells provide an excellent context to address this issue. Notch1 signals initiate T-cell development and increase in intensity during maturation of early T-cell progenitors (ETP) to the DN3 stage. A...