hepatitis c virus is one of the main reasons for chronic liver disease and hepatocellular carcinoma. combination therapy with interferon (peg-ifn-α) and ribavirin (rbv) clear the virus more likely than the others. different factors like virus and host characteristics influence on response to treatment. the most important viral factors include virus genotype and viral load; host factors like gen...

Objective: Interferon-α (IFN) therapy can cause depressive symptom which may lead to drug discontinuation. By interfering with tryptophan pathway, the available level of tryptophan required for serotonin synthesis decreases which could be related to depression. The aim of this study was to evaluate whether soybean diet could improve IFN-induced depression. Materials and Methods: Male mice weigh...

Abstract Background Accumulating evidence suggests tRNA-derived fragments (tRFs) play important roles in cellular homeostasis. Here we aimed to explore aberrant expression of tRFs CD4 + T cells from patients with systemic lupus erythematosus (SLE) and their potential function the SLE pathogenesis. Methods First, small RNA sequencing was performed on four three healthy controls (HCs). Candidate ...

The type I interferon (IFN-I) system is important for antiviral and anticancer immunity. Prolonged activation of IFN/JAK/STAT signaling closely associated with autoimmune diseases. TRIM10 dysfunction may be certain disorders. Here, we observed that the serum protein level lower in patients systemic lupus erythematosus than healthy control subjects. We speculated possible involvement TRIM10-indu...

Davoudi-Monfared et al. (1) report in this journal the results from a clinical trial on coronavirus disease 2019 (COVID-19) patients showing that subcutaneous administration of interferon beta (IFN-β) was associated with more rapid recovery severe acute respiratory syndrome 2 (SARS-CoV-2) infection and decreased mortality. These findings have been corroborated by two recent phase trials during ...

Abstract Immune defenses are triggered by cytokines like interferon-α (IFN-α) and IFN-γ in diverse cells. Both IFNs induce a class of factors termed IFN-stimulated genes (ISGs). Many ISG proteins have antiviral functions. There is growing appreciation that repertoires cell-type specific this bias impacts infection outcomes. However, the cues mechanisms driving these variable responses ill-defin...

objective: oral lichen planus (olp) is a chronic inflammatory disease. immunological factor may act as etiological factor. the cellular immune cells such as t cells are important in pathogenesis. interferon gamma (ifn-γ) and interleukin 4 (il-4) are secreted by t-helper 1 (th1) and th2, respectively. the aim of this study was to investigate the correlation between salivary levels of ifn-γ and i...

Instream flow needs (IFN) assessment studies are performed to provide guidelines for stream water management and to assess the impacts of different water projects such as weirs, dams and stream diversions on the available fish habitat. The physical habitat simulation is one of the IFN assessment methods and also a powerful tool in management of river ecosystem that has not become a common metho...