hla-g is normally expressed on human trophoblast cells. it is a non-classical mhc molecule class i b. the role of hla-g in diabetic type 1 is not known. we investigated the role of ifn-β in induction hla-g expression on the monocyte derived dendritic cells (dc) in diabetes type 1. treatment of dendritic cell with ifn-β in vitro from diabetic patients (n=20) and normal subjects (n=20) resulted t...

introduction: toxoplasma gondii is an obligatory interacelullar parasite that infects nucleated cells in its intermediate hosts. the aim of the present study was to determine the effect of vitamin d3 on the multiplication of t. gondii in peritoneal macrophage of balb/c mice and nitric oxide production by macrophages.  methods: according to usage of vitamin d3 (one dose or seven doses) and infγ ...

background: th1 cells preferentially express cxcr3, ccr5 and ccr6, while ccr3 and ccr4 are predominantly expressed by th2 cell subsets. multiple sclerosis (ms) is a th1 cell-dependant chronic inflammatory disease of the central nervous system, and immunomudolatory cytokines could alter the chemokine expression pattern of these lymphocyte subsets. objective: this study was performed to measure c...

the prevalence of hepatitis c virus (hcv) is approximately 3% around the world. this virus causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. the effectiveness of interferon-α and ribavirin therapy is about 50% and is associated with significant toxicity and cost. hence, generating new vaccines or drugs is an obligation. however, there is no vaccine available for clinical u...

tuberculosis is one of the most common infectious diseases in the world. in recent years, genetically approach has been developed. one of the interesting gene for investigator is ifn-γr1. in this study we determind susceptibility to tuberculosis with polymorphism of ifn-γr1 gene. fifthly patients with smear positive tuberculosis have been chosen randomly. they were matched with 54 healthy contr...

Background Persistent human bocavirus 1 (HBoV1) infection is a common finding in patients suffering from chronic tonsillar disease. However, the associations between HBoV1 and specific immune reactions are not completely known. We aimed to compare vivo expression of T-cell cytokines, transcription factors, type I/III interferons tonsils HBoV1-positive -negative tonsillectomy patients. Methods T...

Viral infection is a significant burden to health care worldwide. Statins, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors, are widely used as cholesterol-lowering drugs. Recently, long-term statin therapy was shown reduce the antiviral immune response; however, underlying molecular mechanisms unclear. Here, we found that simvastatin decreased polyinosinic–polycytidylic acid [poly(I...

Objective: The interleukin-12/interferon-γ (IL-12/IFN-γ) pathway is the most validated cytokine regulating Mycobacterium tuberculosis infection. role of IL-12/IFN-γ axis in protecting against (TB) exhibited people having mutations genes encoding these cytokines. We aimed to study serum levels IL-12 and IFN-γ pediatric their correlation with clinical microbiological features. Material Methods: A...

Interferons (IFN) have antiviral activity against many viruses, including SARS-CoV-2. A combination of IFN-a2b and the antioxidant taurine is widely used in Russian Federation, its has not been studied before. The aim this study was to determine interferon drugs, with without it. included cytotoxicity assays preparations, when stored according instructions at 2–8°C, after 1 month storage temper...