AIMS Reperfusion is mandatory to salvage ischaemic myocardium from infarction, but also induces additional reperfusion injury and contributes to infarct size (IS). Gentle reperfusion (GR) has been proposed to attenuate reperfusion injury, but this remains contentious. We now investigated whether (i) GR reduces IS and (ii) GR is associated with the activation of reperfusion injury salvage kinase...

Fractional flow reserve (FFR) is the ratio of distal coronary pressure to aortic pressure (Pd/Pa) across a stenosis measured during maximal hyperemia, most commonly achieved by the intracoronary or intravenous administration of adenosine. Multiple studies have demonstrated that FFR-guided revascularization improves clinical outcomes compared with angiographic guidance alone. This has resulted i...

Abstract Intumescent flame retardants (IFR) are widely used in the field of retardant polypropylene (PP), but their efficiency and smoke suppression properties need to be further improved. Herein, a Ni‐Al LDH (layered double hydroxide) is obtained successfully by coprecipitation microwave hydrothermal technique as synergist improve flame‐retardant smoke‐suppression triazine‐based IFR. The resul...

OBJECTIVE To determine whether the instantaneous wave-free ratio (iFR) can detect improvement in stenosis significance after percutaneous coronary intervention (PCI) and compare this with fractional flow reserve (FFR) and whole cycle Pd/Pa. DESIGN A prospective observational study was undertaken in elective patients scheduled for PCI with FFR ≤ 0.80. Intracoronary pressures were measured at r...

We show that in the stationary M/G/1 queue, if the service time distribution is with increasing (decreasing) failure rate (IFR (DFR)), then (a) The distribution of the number of customers in the system is also IFR (DFR), (b) The conditional distribution of the remaining service time given the number of customers in the system is also IFR (DFR) and (c) The conditional distribution of the remaini...

BACKGROUND The instantaneous wave-free ratio (iFR) is a new vasodilator-free index of coronary stenosis severity. The aim of this meta-analysis is to assess the diagnostic performance of iFR for the evaluation of coronary stenosis severity with fractional flow reserve as standard reference. METHODS We searched PubMed, EMBASE, CENTRAL, ProQuest, Web of Science, and International Clinical Trial...

Abstract Background In patients undergoing invasive coronary angiography with functional lesion assessment, both fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) measurements can be used to guide revascularization decision-making. The hemodynamic significance of lesions discordant FFR iFR is debated. Purpose This study compared quantitative myocardial perfusion indices as a...

Let G be a group generated by r elements g1, g2, . . . , gr. Among the reduced words in g1, g2, . . . , gr of length n some, say γn, represent the identity element of the group G. It has been shown in a combinatorial way that the 2nth root of γ2n has a limit, called the cogrowth exponent with respect to generators g1, g2, . . . , gr. We show by analytic methods that the numbers γn vary regularl...

BACKGROUND Coronary revascularization guided by fractional flow reserve (FFR) is associated with better patient outcomes after the procedure than revascularization guided by angiography alone. It is unknown whether the instantaneous wave-free ratio (iFR), an alternative measure that does not require the administration of adenosine, will offer benefits similar to those of FFR. METHODS We rando...

BACKGROUND Adenosine-free coronary pressure wire metrics have been proposed to test the functional significance of coronary artery lesions, but it is unexplored whether their diagnostic performance might be altered in patients with diabetes. METHODS We performed a post-hoc analysis of the CONTRAST study, which prospectively enrolled an international cohort of patients undergoing routine fract...