Background: IGF-1 and certain other cytokines have been shown to exert inflammatory/anti-inflammatory roles in chronic joint diseases. Objective: To assess the effect of IGF-1, IL-27 and IL-35, their interaction and their receptor expression in a rheumatoid arthritis model. Methods: Freund’s adjuvant-induced chronic joint inflammation was operated on 160 male rats. Animals were divided into his...

As a tool for measuring the aging process, life span has been invaluable in dissecting the genes that modulate longevity. Studies over the past few decades have identified several hundred genes that can modify life span in model organisms such as yeast, worms, and flies. Yet, despite this vast amount of research, we still do not fully understand how the genes that affect life span influence how...

To investigate the effects and potential mechanisms of chicoric acid (CA) on LPS-induced inflammatory response in A549 cells. 0–800 μM CA was added to cells determine toxicity using MTT assay. Then, 2 μg/mL LPS 50 were simultaneously CA. In order miR-130a-3p IGF-1 cells, infected with inhibitor si RNA IGF-1. The levels cytokines such as IL-1β, IL-6, TNF-α measured by real-time RT-PCR enzyme-lin...

conclusions our findings indicated a lower level of both omentin-1 and igf-1 in women with mets; this might play a role in the pathogenesis of mets. furthermore, the main finding of the current investigation was the association between omentin, visfatin and igf-1; however determining the molecular mechanism of the observed relationships needs further studies. results significantly lower levels ...

Persistent hyperglycemia resulting from diabetes mellitus causes microvascular lesions and long-term diabetic complications, such as nephropathy. The aim of the study was to analyze levels insulin-like growth factors (IGFs), their carrier proteins (IGFBP), markers kidney tissue damage (IL-18, L-FABP, cystatin C, NGAL, KIM-1) in male rats with mellitus, tumor growth, combination. Materials metho...