Interleukin-6 (IL-6) is a cytokine with many activities. It has functions in the regulation of the immune system and the nervous system. Furthermore, IL-6 is involved in liver regeneration and in the metabolic control of the body. On target cells, IL-6 binds to an 80 kDa IL-6 receptor (IL-6R). The complex of IL-6 and IL-6R associates with a second protein, gp130, which thereupon dimerizes and i...

Cytokines are essential modulators of the immune response. In the last decade there has been a number of cytokines considered targets for the development of biological therapies with the goal of blocking their activities and modulate the course of the immune response, primarily in the context of inflammatory diseases. IL-6 was first identified in the mid-1980s [1], but for almost two decades th...

Note: G/C polymorphism at nucleotide -174 (promoter region) Breast cancer prognosis differs between populations. Despite its lower incidence in Blacks when compared to Caucasians, mortality among the former is higher. Genetic factors involved in the molecular pathways regulating tumor development have been adduced to explain these differences, and it has been suggested that the IL-6 gene is a s...

the release of pro-inflammatory cytokines is responsible for the variety of behavioral, neuro-endocrine and neuro-chemical alterations in psychiatric condition. in this study we evaluate relation between depression and il-6 and il-10 in patients undergoing hematopoietic stem cell transplantation (hsct).66 patients in this cross-sectional study from july 2013 until august 2014 for hsct interred ...

Background: Recent studies have shown that cytokines have an important role in the pathogenesis of inflammatory diseases and can be used as prognostic markers. Objective: To evaluate the IL-6/IL-10 ratio in patients with Inherited Epidermolysis Bullosa (EB) as a prognostic marker. Methods: Serum levels of IL-6 and IL-10 were measured in 13 patients with recessive dystrophic EB (RDEB) as well as...