Serial leucocyte counts were made on 24 babies of less than 33 weeks' gestation during the first 5 days of life. The values for mature neutrophils show two important differences from those obtained by previous workers studying term babies, in that the counts were much lower on the first day of life and showed a wider range of values at all ages. In contrast, immature neutrophil counts, expresse...

Background & Aim: Vast variety of plants in various regions of the country and lack of enough information on their chemical combinations, sometimes lead to triggering poisoning and unsatisfied complications. Regarding to fabulous herbal characteristics of Hypricum, many research about poisoning and side effects of high concentrations of H. scabrum have not taken place...

Previous studies have identified patients with susceptibility to bacterial infection associated with lactoferrin deficiency in dysmorphic neutrophils containing abnormal or no secondary granules and abnormal nuclear segmentation. We have investigated the subcellular distribution of vicinal glycol-containing complex carbohydrates in marrow and blood myeloid cells of such a patient using the peri...

Bacterial and fungal sepsis is a major cause of morbidity and mortality in neonates. Infection rates are high in infants treated in intensive care units, with the highest rates, of around 30%, occurring in extremely immature preterm neonates. A survey of neonatal infection at Yale University, ongoing since 1928, has documented a decline in neonatal septic deaths commensurate with the establishm...

Beyond its well-established roles in mediating leukocyte rolling, E-selectin is emerging as a multifunctional receptor capable of inducing integrin activation in neutrophils, and of regulating various biological processes in hematopoietic precursors. While these effects suggest important homeostatic contributions of this selectin in the immune and hematological systems, the ligands responsible ...

In the past differentiation of human neutrophils has been defined by morphology, cytochemistry, or surface markers. In our experiments we have sequenced the various events that occur during the functional differentiation of the normal human neutrophil and have also examined some of the functional properties in relationship to surface markers and biochemical events. Granulocytes were obtained fr...

Neutrophils undergo constitutive apoptosis when aged ex vivo. Recent studies have indicated roles for Fas/CD95 and the nicotinamide adenine dinucleotide phosphate (NADPH)oxidase system in this process. We have investigated the role of protein kinase C (PKC) in neutrophil death. We show that there is proteolysis and activation of the novel isoform PKCd in aged neutrophils and that this process i...

Type I inflammatory cytokines are essential for immunity to many microbial pathogens, including Toxoplasma gondii. Dendritic cells (DC) are key to initiating type 1 immunity, but neutrophils are also a source of chemokines and cytokines involved in Th1 response ignition. We found that T. gondii triggered neutrophil synthesis of CC chemokine ligand (CCL)3, CCL4, CCL5, and CCL20, chemokines that ...