The importance of inflammation in the initiation and development of atherosclerosis has been extensively studied over the last decades.1,2 In particular, much effort has been devoted to elucidating the role of chemokines and their receptors, which play a central part in the atherogenic immune response. Indeed, interfering with the chemokine– chemokine receptor system emerged as both an exciting...

The importance of inflammation in the initiation and development of atherosclerosis has been extensively studied over the last decades.1,2 In particular, much effort has been devoted to elucidating the role of chemokines and their receptors, which play a central part in the atherogenic immune response. Indeed, interfering with the chemokine– chemokine receptor system emerged as both an exciting...

OBJECTIVE To analyse various parameters of sepsis screen singly and in combination to formulate a guideline for the diagnosis of neonatal sepsis. DESIGN A cross-sectional analytical study. PLACE AND DURATION OF STUDY The neonatal intensive care unit at the Paediatric Department, Military Hospital, Rawalpindi, over a period of seven months from 1st June to 31st December 2003. SUBJECTS AND ...

Elicited peritoneal neutrophils of beige (Chediak-Higashi) mice essentially lack activities of the neutral serine proteinases elastase and cathepsin G, which may explain the increased susceptibility to infection of beige mice and Chediak-Higashi patients. We have examined neutrophils of beige mice at earlier points in their development to determine if the proteinase genes are never expressed or...

Myeloid-derived suppressor cells (MDSC) are a diverse population of immature myeloid cells that have potent immune-suppressive activity. Studies in both mice and humans have demonstrated that MDSC accumulate in most individuals with cancer, where they promote tumor progression, inhibit antitumor immunity, and are an obstacle to many cancer immunotherapies. As a result, there has been intense in...

A cow with history of fever, anorexia, sudden milk drop and stiff gait was referred to the Teaching Veterinary Clinical Complex, College of Veterinary Science; Proddatur. Examination of the cow revealed fever, tachycardia, tachypnoea, with ruminal atony associated with mild bloat and dehydration was noticed. The cow exhibited light pain while palpation at brisket region. Hot and pain full edema...

Bacterial infections are important aspects that need to be rapid diagnosis and appropriate treatment with antibiotics. Bacterial infection can cause severe clinical conditions especially premature infants, diabetes mellitus, renal failure patients undergoing hemodialysis, hepatic cirrhosis, hematologic or non-hematologic malignancies, immune deficiency syndrome. Therefore, many laboratory tests...

Several syndromes manifest as recurrent daily fevers, skin lesions, and multisystem inflammation. We describe 4 patients with early-onset recurrent fevers, annular violaceous plaques, persistent violaceous eyelid swelling, low weight and height, lipodystrophy, hepatomegaly, and a range of visceral inflammatory manifestations. Laboratory abnormalities included chronic anemia, elevated acute-phas...

Reliable automated blood cell characterization and quantification remain challenging in pathologic samples, whereas slide reviews due to unnecessary flagging should be avoided. We compared 4 modern hematology analyzers-Abbott Sapphire, Siemens Advia 120, Sysmex XE-2100, and Beckman Coulter DxH 800-regarding complete blood cell count (CBC), leukocyte differential count, and flagging efficacy in ...