After studying the effect of function on the strength of tendon repairs in dogs, Mason and Allen (1941) concluded that immobilisation was necessary for two or three weeks. This had been taught by Mayer (1938) and was followed by Koch (1943) and Bunnell (1948). Since then Miller (1942), Farquharson (1950), Rank and Wakefield (1953), Nemethi (1956), Kelly (1959), Flatt (1959), and Clarkson and Pe...

In situ or on-chip protein array methods use cell free expression systems to produce proteins directly onto an immobilising surface from co-distributed or pre-arrayed DNA or RNA, enabling protein arrays to be created on demand. These methods address three issues in protein array technology: (i) efficient protein expression and availability, (ii) functional protein immobilisation and purificatio...

Periods of immobilisation are often associated with pathologies and/or ageing. These periods of muscle disuse induce muscle atrophy which could worsen the pathology or elderly frailty. If muscle mass loss has positive effects in the short term, a sustained/uncontrolled muscle mass loss is deleterious for health. Muscle mass recovery following immobilisation-induced atrophy could be critical, pa...

Posterior carpometacarpal (CMC) dislocation is a rare condition. Treatment is usually surgical though no strict consensus can be found upon literature review. If diagnosed early and no associated fractures are found, CMC dislocation could benefit from conservative treatment comprising closed reduction and splint immobilisation. We report the case of a 26-year-old man diagnosed with a posterior ...

This paper describes a novel strategy to create a microarray of G-protein Coupled Receptors (GPCRs), an important group of membrane proteins both physiologically and pharmacologically. The H1-histamine receptor and the M2-muscarinic receptor were both used as model GPCRs in this study. The receptor proteins were embedded in liposomes created from the cellular membrane extracts of Spodoptera fru...

The presence of the connective tissue components fibronectin and the different types of collagen was demonstrated by histological and immunohistological methods in the granulation and scar tissue of a healing injury in rat muscle. The effects of physical activity on granulation tissue production, scar formation and muscle regeneration at various stages of healing were studied. It was shown that...

A sensitive and versatile detection scheme based on quantum dot immobilisation on a solid support through bio-orthogonal PCR amplification and labelling has been developed for detection and quantification of gene targets in complex DNA mixtures.

Zirconolite (CaZrTi2O7) has been identified as a candidate ceramic wasteform for the immobilisation and disposal of Pu inventories, which there is no foreseen future use. Here, we provide an ov...