SUMMARY This review discribes some of the morphological tools which have allowed not only to discribe the chemical nature of neuronal pathways in the central nervous system but also to approach their physiology and their functions: Enzyme histochemistry; this technique shows the entity of an enzyme in nervous tissue. Immunocyto-histochemistry; based on antigen­antibody reaction constitute the ...

Background and objectives The relationship between the tumor microenvironment network of key signaling pathways in cancer plays a role occurrence development tumors. Tumor-associated macrophages (TAMs) are important inflammatory cells play an tumorigenesis progression. Macrophages malignant tumors, mainly M2 subtype, promote progression by producing cytokines down-regulating anti-inflammatory i...

The hematopoietic growth factor interleukin-3 (IL-3) promotes the proliferation and maturation of pluripotent myeloid progenitor cells. In the immune system, IL-3 is synthesized by mitogen or antigen-stimulated T lymphocytes. We demonstrate the expression of IL-3 mRNA in mouse brain by in situ hybridization histochemistry and Northern blot analysis. The IL-3 mRNA is localized in discrete areas ...

Kruppel-like factor 8 (KLF8) belongs to the KLF family and has various roles in the regulation of the cell cycle, proliferation and tumor genesis. KLF8 is overexpressed in gastric, ovarian, breast and renal cancer. Additionally, KLF8 may affect invasion and metastasis of tumors. However, whether KLF8 also acts as an ontogeny in lung adenocarcinoma (LAC) remains unknown. The aim of the present s...

The mucin Muc2 is the structural component of the colonic mucus layer. Adult Muc2 knockout (Muc2(-/-)) mice suffer from severe colitis. We hypothesized that Muc2 deficiency induces inflammation before weaning of mother's milk [postnatal day (P) 14] with aggravation of colitis after weaning (P28). Muc2(-/-) and wild-type mice were killed at embryonic day 18.5 and P1.5, P7.5, P14, P21, and P28. C...

Small cell lung cancer (SCLC) originates from pulmonary neuroendocrine cells and accounts for approximately 15% of incidents. Patients with SCLC have a very low survival rate due to fast progression early metastasis. Despite the recent approval immune checkpoint blockade treatment by US FDA, conventional platinum chemotherapy remains first-line which always develops quick drug resistance. To de...

Escherichia coli is a gram-negative bacterium, an intestinal pathogen that can cause inflammation. Antimicrobial peptides are class of small molecule peptides, which has good antibacterial activity against variety gram-positive and negative bacteria. In this regard, the authors aimed to study effect antimicrobial peptide MPX, was administered orally, on wall mice infected with barrier function,...

Problem statement: The digestive tract of animals including rodents has taxonomic and ecologic importance due to its ability in adaptation for different environments. Whereas colon absorbs water and carbohydrates, it has a vital role ecologically and physiologically and enjoys different histological structures in different rodents with various diets. Approach: Different rodent specimens belong ...

Enzyme histochemistry serves as a link between biochemistry and morphology. It is based on metabolization of a substrate provided to a tissue enzyme in its orthotopic localization. Visualization is accomplished with an insoluble dye product. It is a sensitive dynamic technique that mirrors even early metabolic imbalance of a pathological tissue lesion, combined with the advantage of histotopogr...