background recommendations to immunize healthcare workers (hcws) against hepatitis b are well known. however, a proportion of individuals do not respond to the primary standard three-dose hb vaccination schedule. conclusions both the single- and double-dose hb vaccines were adequately immunogenic, and the double-dose hb vaccine was not significantly more immunogenic than the single-dose vaccine...

objective: preventing communicable diseases in the armed forces (af) of a country is considered as a national interest and has a great importance. there are limited data on the efficacy of vaccination of the navy personnel. this study was designed to evaluate both the safety and the immunogenicity of a recombinant hepatitis b (hb) vaccine made by pasteur institute of iran (ipi-rhb), in this tar...

BACKGROUND  Immune response to quadrivalent human papillomavirus (HPV) vaccine delivered at 0, 2, and 6 months in young adolescent females plateaus around 24 months after immunization. Antibody levels >24 months postvaccination using extended dosing schedules is unknown. METHODS  We conducted a follow-up immunogenicity study of adolescent girls in Vietnam who participated in a noninferiority ...

We describe the application of three-dimensional (3D) scattering interferometric (iSCAT) imaging to the measurement of spatial interaction potentials for nano-objects in solution. We study electrostatically trapped gold particles in a nanofluidic device and present details on axial particle localization in the presence of a strongly reflecting interface. Our results demonstrate high-speed (~kHz...

1 U.S. Naval Medical Research Unit No. 6 (NAMRU-6) Callao, Peru 8 2 Walter Reed Army Institute of Research (WRAIR) Silver Spring, Maryland 9 3 Universidad Nacional Mayor de San Marcos Lima, Peru 10 11 12 13 Running Header: Shigella Aotus Challenge Model 14

Background: Immunization against diphtheria, tetanus and pertussis has been applied in Iran since 1950. WHO suggests periodical evaluation of effectiveness of the triple diphtheria-tetanus-whole cell pertussis (DTwP) vaccine, worldwide. Objectives: To determine the immunogenicity of locally manufactured DTwP vaccine administered to preschool children in a number of health centers of Tehran in 2...

Today, potential immunogenicity can be better evaluated during the drug development process, and we have rational approaches to manage the clinical consequences of immunogenicity. The focus of the scientific community should be on developing sensitive diagnostics that can predict immunogenicity-mediated adverse events in the small fraction of subjects that develop clinically relevant anti-drug ...

Like vaccines, biologic proteins can be very immunogenic for reasons including route of administration, dose frequency and the underlying antigenicity of the therapeutic protein. Because the impact of immunogenicity can be quite severe, regulatory agencies are developing risk-based guidelines for immunogenicity screening. T cell epitopes are at the root of the immunogenicity issue. Through thei...

BACKGROUND In June 2009, the World Health Organization declared an A(H1N1) influenza pandemic. In October 2009, the largest vaccination campaign in Canadian history began. The aim of this study was to document paediatricians' knowledge, attitudes and practices (KAP) regarding A(H1N1) pandemic influenza and its prevention by vaccination just after the beginning of the A(H1N1) vaccination campaig...

background: immunization against diphtheria, tetanus and pertussis has been applied in iran since 1950. who suggests periodical evaluation of effectiveness of the triple diphtheria-tetanus-whole cell pertussis (dtwp) vaccine, worldwide. objectives: to determine the immunogenicity of locally manufactured dtwp vaccine administered to preschool children in a number of health centers of tehran in 2...