Abstract Tuberous sclerosis complex (TSC) is a multisystem disorder caused by loss-of-function mutations in TSC1/2 proteins. This results constitutive mTOR activation and predisposes to the development of benign tumours, with renal angiomyolipomas (AMLs) tuber-related drug-resistant epilepsy (DRE) being major causes morbidity mortality adults. Despite central role leukocyte biology beneficial i...