Background Systemic immune-mediated diseases vary in manifestations and pathogenesis. Currently, disease diagnoses treatments are generally based on clinical symptoms some specific serological features. Because the share pathological features, it is difficult to comprehend pathogenesis manage them appropriately. To date, a limited number of studies tried stratify such patients into subgroups us...

The purpose of any classification of leukaemia is to identify distinct biological entities which diVer in aetiology, mechanisms of leukaemogenesis, clinicopathological features, and prognosis. Since the optimal treatment for such entities diVers, their recognition is not only of scientific interest but is also essential for optimal care of patients. Acute leukaemia can be classified in many way...

Background: Fibroblasts are mesenchymal cells that can be readily cultured in the laboratory and play a significant role in epithelialmesenchymal interactions, secreting various growth factors and cytokines that have a direct effect on epidermal proliferation, differentiation and formation of extracellular matrix. They have been incorporated into various tissue-engineered and used for a variety...