Contractile properties of rabbit tibialis anterior muscles were measured after eccentric contraction to investigate the mechanism of muscle injury. In the first experiment, two groups of muscles were strained 25% of the muscle fiber length at identical rates. However, because the timing of the imposed length change relative to muscle activation was different, the groups experienced dramatically...

A study was conducted to see whether a biomechanical model previously validated for predicting the lumbar spine internal loads imposed by the performance of easy and moderately strenuous physical tasks was also adequate for predicting loads imposed by heavy exertions. Lumbar trunk muscle myoelectric activities were measured in 10 healthy young adult men performing a variety of less strenuous an...

The selectivity filter of K+ channels provides specific coordinative interactions between dipolar carbonyl ligands, water, and the permeant cation, which allow for selective flow of K+ over (most importantly) Na+ across the cell membrane. Although a structural viewpoint attributes K+ selectivity to coordination geometry provided by the filter, recent molecular dynamics simulation studies attrib...

It is becoming increasingly clear that mesenchymal stem cell (MSC) differentiation is regulated by mechanical signals. Mechanical forces generated intrinsically within the cell in response to its extracellular environment, and extrinsic mechanical signals imposed upon the cell by the extracellular environment, play a central role in determining MSC fate. This article reviews chondrogenesis and ...

In this paper we present an interactive method for simulating deformable objects using skeletal constraints. We introduce a two-way coupling of a finite element model and a skeleton that is attached to this model. The skeleton pose is determined via inverse kinematics. The target positions of joints are either given by user interactions or forces imposed by the surrounding deformable body. The ...

The effect of thermally generated bulk stochastic forces on the statistical growth dynamics of forwards bifurcating propagating macroscopic patterns is compared with the influence of fluctuations at the boundary of a semiinfinite system, 0 < x. To that end the linear complex Ginzburg-Landau amplitude equation with additive stochastic forcing is solved by a spatial Laplace transformation in the ...

This paper argues that various kinds of displaced structures in English should be licensed by a more explicitly formulated type of rule schema in order to deal with what is called weak connectivity in English. This paper claims that the filler and the gap site cannot maintain the total identity of features but a partial overlap since the two positions need to obey the structural forces that com...

We measure dynamic traction forces exerted by epithelial cells on a substrate. The force sensor is a high-density array of elastomeric microfabricated pillars that support the cells. Traction forces induced by cell migration are deduced from the measurement of the bending of these pillars and are correlated with actin localization by fluorescence microscopy. We use a multiple-particle tracking ...

A physics-based framework for 3-D shape and nonrigid motion estimation for real-time computer vision systems is presented. The framework features dynamic models that incorporate the mechanical principles of rigid and nonrigid bodies into conventional geometric primitives. Through the efficient numerical simulation of Lagrange equations of motion, the models can synthesize physically correct beh...

Cell-to-cell adhesions are crucial in maintaining the structural and functional integrity of cardiac cells. Little is known about the mechanosensitivity and mechanotransduction of cell-to-cell interactions. Most studies of cardiac mechanotransduction and myofibrillogenesis have focused on cell-extracellular matrix (ECM)-specific interactions. This study assesses the direct role of intercellular...