current study was aimed to evaluating protective effects of cornus mas fruit extract (cmfe) in mice treated with methotrexate (mtx). for this purpose, 48 young mature male mice were divided into 6 groups. control group received only normal saline (0.1 mlper day, intraperitoneally), and the second group was administered mtx (20 mg kg-1 perweek, intraperitoneally). the third, fourth and fifth gro...

objective: to determine bilateral effects of unilateral iatrogenic vas deferens trauma (uit) on epididymal sperm characteristics and in vitro fertilizing capacity in an experimental mouse model. methods: experiments were performed on three equal groups each comprising six adult male mice. following anaesthesia, uit was induced by clamping left vas deferens with a mosquito clamp in fully locked ...

background: in this study, we aimed to investigate the ability of transvaginal doppler ultrasonography in predicting in vitro fertilization (ivf) outcome in women undergoing this procedure. materials and methods: in this prospective observational study, 65 infertile women underwent ivf procedure in isfahan, during 2013-2014, were studied. the pulsatility index (pi), resistive index (ri) and pea...

background: despite major advances in assisted reproductive techniques, the implantation rates remain relatively low. some studies have demonstrated that intrauterine infusion of granulocyte colony stimulating factor (g-csf) improves implantation in infertile women. objective: to assess the g-csf effects on ivf outcomes in women with normal endometrial thickness. materials and methods : in this...

background: vitamin d in complex with its receptor by regulating gene expression, endometrium immune response and stimulation of endometrium decidualization can be involved in implantation. so, it seems that the amount of vitamin d in follicular fluids (ff) may have an association with art success. objective: first, we intended to investigate the possible association between levels of follicula...

background: the mitogen-activated protein kinase (mapk) pathway is one of the major signaling pathways that transmit intracellular signals initiated by extracellular stimuli to the nucleus. the stress-activated protein kinase (sapk)/c-jun nh2-terminal kinase is a subfamily of map kinases implicated in cytokine and stress responses. objective: in this study, we have examined total and phosphoryl...

background: the latest studies reported that local endometrial injury is a useful method to improve the success of ivf-icsi outcome. objective: to assess whether local endometrial injury occurred by pipelle in the spontaneous cycle could improve implantation rate, cleavage rate, and pregnancy outcome in the subsequent ivf-icsi cycle in patients who had recurrent ivf failure. materials and metho...

advantages of mild-stimulation have long been appreciated, while there was a called for more patient-friendly approach in ovarian stimulation around 20 years ago (1)...

BACKGROUND As discontinuation in in vitro fertilization (IVF) programs has been associated with a poor prognosis, one hypothesis is that some couple-specific predictive factors in IVF may be shared with opposite effect by both success (i.e. live birth) and treatment discontinuation processes. Our objective was to perform a joint analysis of these two processes to examine the hypothesis of a lin...