The Drosophila glucoside xylosyltransferase Shams xylosylates Notch and inhibits Notch signaling in specific contexts including wing vein development. However, the molecular mechanisms underlying context-specificity of the shams phenotype is not known. Considering the role of Delta-Notch signaling in wing vein formation, we hypothesized that Shams might affect Delta-mediated Notch signaling in ...

T -cell acute lymphoblastic leukemia (T-ALL) is an aggressive leukemia with a poor outcome. The majority of human T-ALL has gain-of-function (activating) mutations in Notch-1,1 implicating Notch-1 as a central component in the pathogenesis of T-ALL. Notch proteins are widely expressed transmembrane receptors involved in many cellular processes such as differentiation, proliferation, and apoptos...

T HE study of the U wave and of its clinical significance depends upon its accurate recognition. Accurate identification of the U wave is also needed for a correct determination of the Q-T duration. This identification is sometimes difficult because of superposition and fusion of the T and U waves. The term "superposition" is applied to patterns in which these waves are only partially merged an...

Notch is a transmembrane receptor that mediates the cell-cell interactions necessary for many cell-fate decisions. Endocytic trafficking of Notch plays important roles in the activation and downregulation of this receptor. A Drosophila O-FucT-1 homolog, encoded by O-fut1, catalyzes the O-fucosylation of Notch, a modification essential for Notch signaling and ligand binding. It was recently prop...

Notch receptors are involved in regulating the balance between cell differentiation and stem cell proliferation during the development of numerous tissues (Artavanis-Tsakonas, S., Matsuno, K., Fortini, M. E., 1995. Notch signaling. Science 268, 225-232). Here the expression of all four vertebrate Notch genes, their ligands, and some down-stream targets is analyzed during mouse pancreatic organo...

The Notch signaling pathway is highly conserved across different animal species and plays crucial roles in development and physiology. Regulation of Notch signaling occurs at multiple levels in different tissues and cell types. Here, we show that the histone deacetylase HDAC1 acts as a positive regulator of Notch signaling during Drosophila wing development. Depletion of HDAC1 causes wing notch...

Little is known of microRNA interactions with cellular pathways. Few reports have associated microRNAs with the Notch pathway, which plays key roles in nervous system development and in brain tumors. We previously implicated the Notch pathway in gliomas, the most common and aggressive brain tumors. While investigating Notch mediators, we noted microRNA-326 was upregulated following Notch-1 knoc...

Aim: The recognition of the scapula anatomy and visible variations is important in surgical treatments arthroscopic procedures case any diseases shoulder. morphological morphometric characteristics scapular notch on superior margin are very important. Because compression suprascapular nerve extending inside causes entrapment neuropathy. Therefore, present study was planned order to contribute u...

The inclined air-curtain technology was applied to build an inclined air-curtain range hood. A draft generator was applied to affect the inclined air-curtain range hood in three directions: lateral (θ=0°), oblique (θ=45°), and front (θ=90°). The three suction flow rates provided by the inclined air-curtain range hood were 10.1, 10.9, and 12.6 m(3)/min. The laser-assisted flow visualization tech...