The debate over C-H-0 hydrogen bonds lasted for many years before Taylor and Kennard surveyed the Cambridge Structural Database in 1982 and extracted strong statistical evidence in favor of such attractive interactions.' Further work by a number of other groups have concluded that although C-H*-0 bonds are much weaker than traditional hydrogen bonds (X-H-eX, where X = 0 or N) they are nonethele...

Purpose: The development of new effective therapeutic agents with minimal side effects for prostate cancer (PC) treatment is much needed. Indirubin, an active molecule identified in the traditional Chinese herbal medicine—Qing Dai (Indigo naturalis), has been used to treat leukemia for decades. However, the anticancer properties of Natura-alpha, an indirubin derivative, are not well studied in ...

philes Pseudomonas indigofera (Shiio et al., 1965) and Chlorella pyrenoidosa (John 8c Syrett, 1967) is apparently similar. In mutant PC2 NG35 cells the lyase accounts for 16 % of the soluble proteins. The corresponding proportion of malate synthase is 2.5% in the wild-type and 6% in the mutant. Themolecularweightsof thenativeenzymes, determined by gelfiltrationonaSepharose 6B column, are given ...

The present study aimed to investigate the effect of hydroalcoholic extract of Morinda tinctoria Roxb fruit on inhibition of growth and induction of apoptosis in human prostate carcinoma cells (PC-3) and lung carcinoma (A549) cells. Morinda tinctoria Roxb hydro alcoholic fruit extract (MTHFE) was taken to in vitro studies, like phytochemical screening, MTT assay, cell induced apoptosis. Dose de...

The literature does not present any information on ultrasonic assisted extraction of phenolic compounds from Coreopsis tinctoria Nutt. fruits using solvents with different polarities. The objective of this paper is to highlight the potential of ultrasound assisted extraction in the fast preparation of extracts rich in polyphenols of Coreopsis tinctoria Nutt. fruits in good yields. Several param...

In Brazil and several other Latin American countries, Chagas’ disease still constitutes a serious medical and social problem, and there is a need to develop new, more-potent drugs with fewer side effects to effectively treat this disease. We investigated the antitrypanosomal effect of a crude extract, fractions, and a semi-purified subfraction rich in a mixture of isomeric labdane sesquiterpene...

To assay the in vitro xanthine oxidase and Tyrosinase inhibitory activity of the alkaloid fractions of the leaves of Indigofera spalathoides and to determine its enzyme inhibition mechanism. Xanthine oxidase and Tyrosinase inhibitory activity was assayed spectrophotometrically under aerobic conditions and the degree of enzyme inhibition was determined by measuring the increase in absorbance at ...