The potential involvement of neutrophils in the pathogenesis of indomethacin induced ulceration of the gastric antrum in the re-fed rat was studied. Indomethacin was associated with a time dependent increase in the extent and severity of ulceration, blood neutrophilia, neutrophil infiltration into the gastric antrum, and calcium ionophore induced immunoreactive leukotriene B4 (LTB4) release fro...

Bioinequivalence of glassy and crystalline indomethacin was investigated in rabbits. In vivo absorption studies were carried out by determining the plasma levels of indomethacin following oral and rectal administrations in rabbits. The A UC (area under the concentration–time curve) and the maximum plasma level following the administration of the glassy preparation were larger than those in the ...

Six preterm infants with a persistent ductus arteriosus, who failed to improve with conventional medical management, received indomethacin in an attempt to close the duct pharmacologically. All infants weighed less than 1000 g when the drug was administered. All showed a transient response to indomethacin; however, no infant demonstrated a permanent response, even though 5 of the 6 received mul...

the mechanisms underlying cerebral vasodilatation during hypercapnia are not fully understood. to examine the role of nerves and prostaglandins in the regulation of basal blood flow and in hypercapnia-induced vasodilatation in the cerebral blood vessels of rabbit. cerebral blood flow was measured by laser doppler flow-meter in 18 nzw rabbits anesthetized with sodium pentobarbital.  tetrodetoxin...

prostaglandin £j (pge-^) and indomethacin, a nonstroidal antiinflammatory drug, were separately administered during ortliodontic tooth movement in rats. at the beginning, an orthodontic appliance was placed and activated in male albinos rats. in tlie first examination, the experimental group received submucosal injections of pge-y (10 mg/kg/day) near the first maxillary riglit molars, and alcoh...

current research attempted to compare the effect of 10-day oral supplementation with saffron and indomethacin in the prevention of delayed onset muscle soreness (doms). thirty-nine healthy and inactive male students divided into three groups: saffron (300 mg), indomethacin (75 mg), and control groups. muscle soreness protocol performed with 80% of 1rm in four sessions and each session had 20 re...

BACKGROUND At present there are several kinds of medicine for treating acute gout arthritis (AGA). This study compared the efficacy and safety of prednisolone, etoricoxib, and indomethacin in the treatment of AGA. MATERIAL/METHODS This was an open-label, randomized, active-comparator study in patients with AGA. Patients were randomized to 4 days of prednisolone 35 mg qd, etoricoxib 120 mg qd,...

Previous studies by us and others have demonstrated that PGE2 and thromboxane (Tx) B2 are produced in the fetal and neonatal brain during cerebral hypoperfusion. The present study was to test the hypotheses that indomethacin would alter the cerebral blood flow (CBF) response to reduced cerebral perfusion pressure in late-gestation fetal sheep by inhibiting the local prostanoid production. We st...

We studied the in vitro effect of indomethacin, hydrocortisone, sulphasalazine, and its metabolites sulphapyridine (SP) and 5-amino salicylic acid (5-ASA) on peripheral blood mononuclear cells (PBMC) from 49 patients with inflammatory bowel disease and 34 controls. Indomethacin caused a highly significant increase in the PBMC response to the mitogen PHA-P compared with controls (P less than 0.0...

We have studied prospectively the effect of indomethacin on the development of heterotopic ossification (HO) after the internal fixation of acetabular fractures. After operation 107 patients randomly received either a six-week course of indomethacin or no treatment against HO. Plain radiographs of 101 patients at a mean of 7.9 months after surgery showed HO in 47.4% of the 57 patients who recei...