objective infantile spasms (is) or west syndrome is a convulsive disease characterized by brief, symmetric axial muscle contractions (neck, trunk, and/or extremities).the therapy universally recognized as most effective in the treatment of is, is treatment with the adrenocorticotropic hormone (acth) or oral corticosteroids. this therapy however has important side effects. many studies have soug...

how to cite this article:  fallah r, salor f, akhavan karbasi s, motaghipisheh h. randomised clinical efficacy trial of topiramate and nitrazepam in treatment of infantile spasms. iran j child neurol. 2014 winter; 8(1):12-19. objective infantile spasms (is) are among the most catastrophic epileptic syndromes of infancy. the purpose of this study was to compare efficacy and safety of topiramate ...

OBJECTIVE To review the result of the infantile spasms' treatment with sodium valproate followed by nitrazepam or clonazepam. STUDY DESIGN Descriptive retrospective study. SETTING Srinagarind Hospital, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. MATERIAL AND METHOD Twenty-four infantile spasms admitted between January 1994 and December 2003 we...

Correspondence: Chang-Yong Tsao 700 Children’s Dr Columbus, Ohio 43205, USA Tel +1 614-722-4691 Fax +1 614-722-4633 email changyong.tsao@ nationwidechildrens.org Abstract: Infantile spasms are an epilepsy syndrome with distinctive features, including age onset during infancy, characteristic epileptic spasms, and specific electroencephalographic patterns (interictal hypsarrhythmia and ictal volt...

Infantile spasms are an epilepsy syndrome with distinctive features, including age onset during infancy, characteristic epileptic spasms, and specific electroencephalographic patterns (interictal hypsarrhythmia and ictal voltage suppression). Adrenocorticotropic hormone (ACTH) was first employed to treat infantile spasms in 1958, and since then it has been tried in prospective and retrospective...

Case presentation: M.S.G, 1 year old, previously healthy, suffered intoxication by acaricide (organophosphate and pyrethroid) in November 2021. Patient presented seizures, vomiting, bronchoaspiration, pneumonia, severe respiratory distress two cardiorespiratory arrests. The magnetic resonance imaging showed hemorrhagic laminar cortical necrosis slight accentuation of sulci brain fissures. He wa...

The solubility enhancement of diazepam and nitrazepam in water was analyzed depending on temperature and amount of α-cyclodextrin (α-CD), β-cyclodextrin (β-CD) and 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD). The interactions of drug-cyclodextrin in solution were investigated by the phase-solubility analysis. Diazepam (nitrazepam) content in aqueous complexation medium was analyzed UV spectropho...

The behavioral effect of brotizolam was investigated in mice and rats, in comparison with those of diazepam, nitrazepam and estazolam. Locomotor activity of rats in an open field situation was slightly increased with smaller doses of brotizolam and estazolam and with larger doses of nitrazepam, while it was decreased with large doses of brotizolam and estazolam. The anticonflict effect of broti...

Accurate methods are described for the qualitative and quantitative determination of medazepam, diazepam, and nitrazepam in 5 ml of whole blood. Medazepam and diazepam are analyzed intact and nitrazepam is chromatographed as its trimethylsilyl derivative by flame-ionization gas-chromatography on “1% OV-17.” A supplementary column of “2% OV-1” is used to separate nitrazepam TMS from diazepam whe...