abstract introduction: resent studies have been shown beneficial effects of hyperoxia pretreatment against ischemia-reperfusion injury in different organs. the aim of the present study was to investigate early and late effects of normobaric hyperoxia (≥95% o2) pretreatment on ischemia-reperfusion injuries in isolated rat hearts. methods: following 60 and 180 minutes of hyperoxia, rat hearts wer...

Myocardial infarction is a common presentation of coronary artery disease and the leading cause of death worldwide. The present study was investigated potential resistance to ischemia-reperfusion (I/R) injuries following administration of methanolic (MeOH) extract of Scrophularia frigida (S. frigida) in isolated rat heart. Male Wistar rat hearts (n= 8-10) were isolated and allowed to equilibrat...

BACKGROUND N-terminal brain-type natriuretic peptide (NT-pro BNP) and cardiac troponin T (cTnT) after acute myocardial infarction (AMI) have proven useful for prediction of prognosis and may be valuable for assessment of left ventricular function and infarct size. The aim of the present study was to correlate infarct size and left ventricular function determined by cine and late gadolinium enha...

AIMS We studied the time-dependent relationships between microvascular obstruction (MO), infarct size, and left ventricular (LV) remodelling after acute myocardial infarction (MI). METHODS AND RESULTS Forty-two consecutive patients with first-time ST-elevation MI, single-vessel disease, successfully treated with primary percutaneous coronary intervention (PCI) were included. Microvascular obs...

UNLABELLED Toll-like receptor 4 (TLR4) mediates innate immune responses following endotoxemia and myocardial ischaemia-reperfusion (I/R) injury. Pre-treatment with the major TLR4 ligand lipopolysaccharide (LPS) reduces infarct size. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) play a crucial role in endotoxemia possibly also determining I/R injury. AIMS We investigat...

PURPOSE To develop a computer algorithm to measure myocardial infarct size in gadolinium-enhanced magnetic resonance (MR) imaging and to validate this method using a canine histopathological reference. MATERIALS AND METHODS Delayed enhancement MR was performed in 11 dogs with myocardial infarction (MI) determined by triphenyltetrazolium chloride (TTC). Infarct size on in vivo and ex vivo imag...

Myocardial infarction (MI) connotes an appropriate sense of urgency to both healthcare workers and the lay community. The heightened risk of death in the period immediately after the acute coronary event makes MI a medical emergency in which response times are measured in minutes. Clinical signs, symptoms, and electrocardiographic evaluations currently are supplemented by highly specific cardia...

Recently a potent anti-inflammatory effect of hydroalcoholic extract of the aerial parts of the sterile stems of Stachys inflata has been reported. This study examined whether hydroalcoholic extract isolated from aerial parts of non-flowering stems of Stachys inflata (standardized to contain 4.5% caffeic acid derivatives) reduce myocardial infarct size arising from coronary artery occlusion (30...