background: the c1019t polymorphism of the connexin-37 (gja4) gene is a single-nucleotide polymorphisms involved in atherosclerotic plaque rupture and atherosclerosis predisposition. we examined the association between the c1019t polymorphism of the gja4 gene and the occurrence of myocardial infarction (mi) in patients with premature coronary artery disease (cad). methods: our study recruited 1...

conclusions we showed that patients with metabolic syndrome have larger infarct size compared to control subjects. background infarct size is an important surrogate end point for early and late mortality after acute myocardial infarction. despite the high prevalence of metabolic syndrome in patients with atherosclerotic diseases, adequate data are still lacking regarding the extent of myocardia...

conclusions: patent coronaries of ua/nstemi patients have a trend to higher tfcs compared to normal values. presence of significant coronary lesions in these patients significantly increases tfc. objectives: the present study is aimed to measure the tfc in the coronary arteries of ua/nstemi patients to find abnormalities in diseased or patent vessels and compare with the normal values. patients...

introduction: telomeres are repetitive sequences of ttaggg section that find at two ends of eukaryotic chromosomes and they shield chromosome ends. telomere shortening in patients with myocardial infarction has been reported. shelterin complex's role is essential in telomere length regulation. telomeric repeat binding factors 1 and 2 (trf1 and trf2) are the most important sheltrein complex...

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aim: oxidative stress plays a crucial role in the pathophysiology of ischemic stroke. since water-solublefullerene derivatives act as the potent scavenger of oxygen free radicals in biological systems, we aimedto investigate the possible protective effects of fullerol nanoparticles on brain infarction and edema intransient model of focal cerebral ischemia in rat.materials & methods: experiment ...

background: epidemiological studies have illustrated that exposure to atmospheric nitrogen oxides (no2/nox) is responsible for an increased risk of acute or chronic diseases such as cancer. in this study the health risks associated with nitrogen dioxide (no2) were assessed in the city of kermanshah, the capital of kermanshah province, iran. methods: data on hourly no2 levels that had been measu...

massive cerebral infarction is often accompanied by early death, secondary to brain edema and trans-tentorial herniation. several reports indicate beneficial effects of decompressive craniectomy in this situation, but the efficacy of this procedure is still a matter of debate. a n experimental study in a period of3 years was done on2 3 patients with brain edema due to massive cerebral infarctio...

      In this study, the changes of renin system activity and the effects of aspirin therapy on the plasma renin activity ( PRA) in myocardial infarction were investigated. Fifty nine patients with myocardial infarction were selected. By suppressed in the former group which was statistically significant ( p<0.01).   

conclusions our findings indicate that fullerenol nanoparticles decrease the brain infarction through enhancement of the sod activity during cerebral ischemia-reperfusion injury. results occlusion of mca induced considerable infarction and lesion in ischemic hemispheres of control ischemic rats (527 ± 59 mm3) in accompany with a decrease in the glutathione content (45%), and sod activity (29%) ...