a 78-year-old woman presented with epigastric pain following the use of non-steroidal anti-inflammatory drugs (nsaids) for joint pain relief. she underwent ugi endoscopy. during ugi endoscopy she suffered from severe retching despite the use of sedatives. at 6 hours after the procedure, she developed raccoon eyes with chemosis. biopsy from the gastrointestinal (gi) mucosa revealed amyloidosis.

INTRODUCTION Inflammatory pain is the result of increased excitability of peripheral nociceptive sensory fibres produced by the action of inflammatory mediators (Linley et al., 2010). Unlike nociceptive pain, wherein the pain sensation is not felt after removal of stimulus, in inflammatory pain, pain sensation resulting from tissue injury occurring due to exposure of high intensity stimulus con...

STUDY DESIGN Retrospective study. PURPOSE To determine whether low-dose tramadol plus non-steroidal anti-inflammatory drug combination therapy could prevent the transition of acute low back pain to chronic low back pain. OVERVIEW OF LITERATURE Inadequately treated early low back pain transitions to chronic low back pain occur in approximately 30% of affected individuals. The administration ...

objective: crocin and safranal are the main components of saffron, and have many biological functions such as anti-inflammatory and antioxidant activities. in the present study, we investigated the effects of crocin, safranal, morphine, diclofenac and naloxone in combined and separately on formalin-induced orofacial pain in rats. materials and methods: subcutaneous injection of a diluted formal...

joint pain is one of the most common complaints with many possible causes.some medicines used for joint pain relief such as nsaids have substantial and frequent side effects. topical route possibly reduces adverse reactions by maximizing local delivery and minimizing systemic toxicity. throughout history, plants have been the most important sources of medicines for human health and iranian trad...

Joint pain is one of the most common complaints with many possible causes.Some medicines used for joint pain relief such as NSAIDs have substantial and frequent side effects. Topical route possibly reduces adverse reactions by maximizing local delivery and minimizing systemic toxicity. Throughout history, plants have been the most important sources of medicines for human health and Iranian Trad...

UNLABELLED Cav2.3 (R-type) voltage-activated Ca(2+) channels (VACCs), encoded by the calcium channel, voltage-dependent, R-type, α1E subunit (CACNA1E) gene, are responsible for transmission of somatic inflammatory pain, and activation of antinociception elicited by visceral inflammatory pain stimuli. Carriers of the minor G allele of the rs3845446 single-nucleotide polymorphism (SNP) of the CAC...

Pain is a manifestation of rheumatoid arthritis (RA) that mediated by inflammatory and non-inflammatory mechanisms negatively affects quality life. Recent findings from Phase 3 clinical trial showed patients with RA who were treated Janus kinase 1 (Jak1) 2 (Jak2) inhibitor achieved significantly greater improvements in pain than those tumor necrosis factor blocker; both treatments resulted simi...

chronic recurrent multifocal osteomyelitis (crmo) is an inflammatory bone disease usually affecting children. a 9-year old boy presented with recurrent lower extremities pain and discomfort lasting for two years. in every time, symptoms vanished after several weeks. the patient received antibiotics only in one period of bone pain. in other occasions the patient didn’t received any antibiotics. ...

Although pain is a major human affliction, our understanding of pain mechanisms is limited. TRPV1 (transient receptor potential vanilloid subtype 1) and TRPV4 are two crucial receptors involved in inflammatory pain, but their roles in EA- (electroacupuncture-) mediated analgesia are unknown. We injected mice with carrageenan (carra) or a complete Freund's adjuvant (CFA) to model inflammatory pa...