AIM Quadruple test is used for Down's syndrome screening in the second trimester of pregnancy. The aim of this study was to investigate differences in quadruple test parameters between pregnancies achieved by assisted reproductive treatments (ART) and spontaneous conception. MATERIALS AND METHODS We retrospectively compared levels of alfa-fetoprotein (AFP), unconjugated Estriol (uE3), inhibin...

Aims: Preterm labor (PTL) is one of the most important medical community problems and the main cause of infant morbidity and mortality after congenital anomalies. Several studies have shown a significant association between the abnormal levels of quadruple test with PTL. However, there is no general agreement on the value of quadruple tests for predicting complications among studies. This study...

Background: Abnormal levels of the markers AFP, hCG, and uE3 could be useful in predicting adverse pregnancy outcomes. This study was designed to determine the correlation between second trimester maternal serum markers and adverse pregnancy outcome (APO). Methods: In this historical cohort study, we randomly followed 231 obstetric patients with quadruple screening test in 14-18 weeks of ges...

Maternal serum analyte screening is an integral component of contemporary antenatal care. Based on elevated MSAFP levels, 85% to 90% of NTDs (e.g., anencephaly or spina bifida) can be detected. Using a combination of serum analytes (e.g., MSAFP, hCG, UE3) 55% to 60% of fetal Down's syndrome can be detected. Future strategies for Down's syndrome screening may include the use of new markers such ...

Background: Analytical error affects 2nd-trimester maternal serum screening for Down syndrome risk estimation. We analyzed the between-laboratory reproducibility of risk estimates from 2 laboratories. Methods: Laboratory 1 used Bayer ACS180 immunoassays for -fetoprotein (AFP) and human chorionic gonadotropin (hCG), Diagnostic Systems Laboratories (DSL) RIA for unconjugated estriol (uE3), and DS...

BACKGROUND Analytical error affects 2nd-trimester maternal serum screening for Down syndrome risk estimation. We analyzed the between-laboratory reproducibility of risk estimates from 2 laboratories. METHODS Laboratory 1 used Bayer ACS180 immunoassays for alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCG), Diagnostic Systems Laboratories (DSL) RIA for unconjugated estriol (uE3), a...

background: abnormal levels of the markers afp, hcg, and ue3 could be useful in predicting adverse pregnancy outcomes. this study was designed to determine the correlation between second trimester maternal serum markers and adverse pregnancy outcome (apo). methods: in this historical cohort study, we randomly followed 231 obstetric patients with quadruple screening test in 14-18 weeks of gestat...