The effects of dietary administration of capsaicin and rotenone on 4-nitroquinoline 1-oxide (4-NQO)-induced tongue tumorigenesis were investigated in male F344 rats. In pilot studies, gavage with capsaicin and rotenone elevated the phase II enzymes glutathione S-transferase (GST) and quinone reductase (QR), in the liver and tongue. Also, a 10 week period of feeding of 500 p.p.m. capsaicin or ro...

Verbal initiation, suppression and strategy generation/use are cognitive processes widely held to be supported by the frontal cortex. The Hayling Test was designed to tap these cognitive processes within the same sentence completion task. There are few studies specifically investigating the neural correlates of the Hayling Test but it has been primarily used to detect frontal lobe damage. This ...

Present study deals with the prediction of crack initiation angle for mixed mode (I/II) fracture using finite element techniques and J-Integral based approach. The FE code ANSYS is used to estimate the stress intensity factor numerically. The estimated values of SIF were incorporated into six different crack initiation angle criteria to predict the crack initiation angle. Single edge crack spec...

E mergency physicians face numerous questions regarding proper management of patients and selection ofthe best laboratory test or imaging every day. Knowledge on screening performance characteristics of the diagnostic tools used in this department plays an important role in finding the answers to these questions. We assessed these characteristics in the previous parts of educational article ser...

PURPOSE The goal in this study was to compare rates of visual field (VF) change before and after the initiation of treatment in participants originally randomized to the observation arm of the Ocular Hypertension Treatment Study (OHTS). METHODS We included OHTS participants originally randomized to observation and excluded those who reached non-POAG endpoints. VF progression was determined us...

INTRODUCTION In a patient with hyperthyroidism, the detection of elevated thyroid hormone concentration with measurable thyroid-stimulating hormone (TSH) value poses considerable diagnostic difficulties. CLINICAL PICTURE This 38-year-old lady presented with clinical features of thyrotoxicosis. Her serum free thyroxine concentrations were unequivocally elevated [45 to 82 pmol/L (reference inte...

PURPOSE To assess change in hospitalization and cost of care from 6 months pre- to 6 months post-initiation on any depot antipsychotic among schizophrenia patients. PATIENTS AND METHODS Using a large United States commercial claims and encounters database, patients younger than 65 years diagnosed with schizophrenia were identified. Patients initiated on a depot antipsychotic were studied in a...

PURPOSE This paper aimed to investigate motor proficiency in fine and gross motor function, with a focus on reaction time (RT) and movement skill, in patients with fibromyalgia (FM) and chronic fatigue syndrome (CFS) compared to healthy controls (HC). METHODS A total of 60 individuals (20 CFS, 20 FM, and 20 HC), age 19-49 years, participated in this study. Gross motor function in the lower ex...

BACKGROUND The effect of initiation of levodopa therapy on the memory functions in patients with Parkinson's disease remains poorly understood. AIMS To evaluate the effect of initiation of levodopa therapy on memory, in patients with early Parkinson's disease. SETTINGS AND DESIGN Prospective case control study. MATERIALS AND METHODS Seventeen patients with early Parkinson's disease were e...