BACKGROUND AND AIMS Curcumin is a hydrophobic polyphenol derived from turmeric, a traditional Indian spice. Curcumin exhibits various biological functions, but its clinical application is limited due to its poor absorbability after oral administration. A newly developed nanoparticle curcumin shows improved absorbability in vivo. In this study, we examined the effects of nanoparticle curcumin (n...

Although nanoparticle-protein conjugates have been synthesized for numerous applications, bioconjugation remains a challenge, often resulting in denaturation or loss of protein function. This is partly because the protein-nanoparticle interface is poorly understood, which impedes the use of nanoparticles in nanomedicine. Although the effects of nanoparticle ligand and material on protein struct...

MRI has been used extensively to noninvasively track the location of cells labeled with superparamagnetic iron-oxide nanoparticles (SPIOs) in vivo. Typically, SPIOs are employed as a negative contrast agent which makes it difficult to differentiate labeled cells from extraneous sources of inhomogeneity and actual voids in the image. As a result, several novel approaches have been put forth to o...

Highly flexible, robust, and sensitive infrared nanosensors were fabricated based on carbon nanoparticles that were synthesized through a simple and low-cost flame method. The infrared nanosensor devices showed sharp infrared photoresponse with a response time of ∼68 ms and a maximum photocurrent change of ∼52.9%. The devices showed a superhydrophobic property with a contact angle larger than 1...

Solving the inverse problem of nanoparticle characterization has the potential to advance science and benefit society. While considerable progress has been made within a framework based on the scattering of surface plasmon-polaritons, an aspect not heretofore considered is the quantification of uncertainty in the estimation of a nanoparticle characteristic. Therefore, the present article offers...

Purpose. The study reports evaluation of different purification processes for removing surplus surfactant and formulating stable nanoparticle dispersions. Methods. Nanoparticle formulations prepared from poly(D,L-lactide-co-glycolide) and polyvinyl alcohol (PVA) were purified by a diafiltration centrifugal device (DCD), using 300K and 100K molecular weight cut-off (MWCO) membranes and a tangent...

Biodistribution of nanoparticles is dependent on their physicochemical properties (such as size, surface charge, and surface hydrophilicity). Clear and systematic understanding of nanoparticle properties' effects on their in vivo performance is of fundamental significance in nanoparticle design, development and optimization for medical applications, and toxicity evaluation. In the present study...

The formation of complexes between nanoparticles and polyelectrolytes is a key process for the control of the reactivity of manufactured nanoparticles and rational design of core shell nanostructures. In this work, we investigate the influence of the nanoparticle dielectric constant on the adsorption of a linear charged polymer (polyelectrolyte) at the surface of a neutral nanoparticle. The pol...

Measurements of magneto-optical relaxation signals of magnetic nanoparticles functionalized with biomolecules are a novel biosensing tool. Upon transmission of a laser beam through a nanoparticle suspension in a pulsed magnetic field, the properties of the laser beam change. This can be detected by optical methods. Biomolecular binding events leading to aggregation of nanoparticles are ascertai...