نتایج جستجو برای: integrin

تعداد نتایج: 24065  

Journal: :Faculty reviews 2021

Thrombocytopoiesis is a complex process beginning at the level of hematopoietic stem cells, which ultimately generate megakaryocytes, large marrow cells with distinctive morphology, and then, through terminal maturation, megakaryocytes shed thousands platelets into circulation. This controlled by intrinsic extrinsic factors. Emerging data indicate that an important control on late stages thromb...

Journal: :Japanese Journal of Thrombosis and Hemostasis 2009

ژورنال: :علوم دامی ایران 2010
ملک شاکری حمید کهرام عبدالحسین شاهوردی احمد زارع شحنه حسین بهاروند

هدف از مطالعه حاضر ارزیابی اثر ماتریکس برون سلولی نانو رشته ای پلی آمید بر تکثیر و عملکرد سلول های بنیادی اسپرماتوگونی (sscs) بچه موش 6 رو در محیط in vitro بوده است. سلول های بنیادی اسپرماتوگونی، از بیضه موش 6 روزه جدا شده و در خانه های یک ظرف کشت 6 خانه ای (3 خانه آن توسط ورقه نانوفیبر پوشانده بوده) به طور جداگانه در حضور فاکتورهای رشد gdnf bfgf و egf با سه بار تکرار کشت داده شدند. تعداد کلنی ...

2014
Yumin Zheng Shundong Ji Andrzej Czerwinski Francisco Valenzuela Michael Pennington Shuang Liu

This study sought to evaluate FITC-conjugated cyclic RGD peptides (FITC-RGD2, FITC-3P-RGD2, and FITC-Galacto-RGD2) as fluorescent probes for in vitro assays of integrin αvβ3/αvβ5 expression in tumor tissues. FITC-RGD2, FITC-3P-RGD2, and FITC-Galacto-RGD2 were prepared, and their integrin αvβ3/αvβ5 binding affinity was determined using the displacement assay against (125)I-echistatin bound to U8...

2013
Claudia S. Priglinger Christoph M. Szober Siegfried G. Priglinger Juliane Merl Kerstin N. Euler Marcus Kernt Gabor Gondi Jennifer Behler Arie Geerlof Anselm Kampik Marius Ueffing Stefanie M. Hauck

Proliferative vitreoretinopathy (PVR) is a blinding disease frequently occurring after retinal detachment surgery. Adhesion, migration and matrix remodeling of dedifferentiated retinal pigment epithelial (RPE) cells characterize the onset of the disease. Treatment options are still restrained and identification of factors responsible for the abnormal behavior of the RPE cells will facilitate th...

2015
Nicola De Franceschi Hellyeh Hamidi Jonna Alanko Pranshu Sahgal Johanna Ivaska

Integrins are a family of transmembrane cell surface molecules that constitute the principal adhesion receptors for the extracellular matrix (ECM) and are indispensable for the existence of multicellular organisms. In vertebrates, 24 different integrin heterodimers exist with differing substrate specificity and tissue expression. Integrin-extracellular-ligand interaction provides a physical anc...

2013
Zhi-Hong Xue Chen Feng Wei-Ling Liu Suet-Mien Tan

Integrins mediate cell-cell and cell-extracellular matrix attachments. Integrins are signaling receptors because their cytoplasmic tails are docking sites for cytoskeletal and signaling proteins. Kindlins are a family of band 4.1-ezrin-radixin-moesin-containing intracellular proteins. Apart from regulating integrin ligand-binding affinity, recent evidence suggests that kindlins are involved in ...

Journal: :The EMBO journal 2014
Gian Maria Sarra Ferraris Carsten Schulte Valentina Buttiglione Valentina De Lorenzi Andrea Piontini Massimiliano Galluzzi Alessandro Podestà Chris D Madsen Nicolai Sidenius

The urokinase-type plasminogen activator receptor (uPAR) is a non-integrin vitronectin (VN) cell adhesion receptor linked to the plasma membrane by a glycolipid anchor. Through structure-function analyses of uPAR, VN and integrins, we document that uPAR-mediated cell adhesion to VN triggers a novel type of integrin signalling that is independent of integrin-matrix engagement. The signalling is ...

Journal: :Journal of Crohn's & colitis 2013
Toshihiko Sugiura Shunsuke Kageyama Ayatoshi Andou Tomoko Miyazawa Chieko Ejima Akira Nakayama Taeko Dohi Hiroyuki Eda

BACKGROUND AND AIMS Inhibition of lymphocyte trafficking by treatment with an anti-α4 integrin antibody has been clinically validated as a therapeutic approach for inflammatory bowel disease (IBD), and the orally effective 'anti-α4 integrin therapy' may be more convenient in clinical practice. The aim of this study was to investigate the pharmacological profile and anti-inflammatory effect of a...

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