نتایج جستجو برای: integrin

تعداد نتایج: 24065  

Journal: :acta medica iranica 0
shakibaei m

when grown in monolayer culture at low density and with the addition of serum, cartilage cells dedifferentiate or are overgrown by fibroblast-like cells. the aim of this study was to optimize the cultivation of chondrocytes in monolayer culture and to slow down their transformation or their overgrowth by fibroblast-like cells. the interaction between chondrocytes and cartilage-specifc matrix is...

Journal: :Advanced nanoBiomed research 2022

Platelet adhesion and activation are mediated by integrin αIIbβ3 clustering, which is crucial for the hemostatic function of platelets. In an activated state, integrins provide connection between extracellular matrix actin cytoskeleton through a variety cytoplasmic proteins, such as talin. Here, droplet-based microfluidics applied to generate cell-sized giant unilamellar vesicles (GUVs) with de...

Kabeer Ahmad Khan Sharique Ahmad Shirish Bhatnagar Shivam Shingla Sufia Ahmad Khan,

The hallmarks of leukocyte adhesion deficiency (LAD) are defects in the leukocyte adhesion process, marked leukocytosis and recurrent infections. These molecular and clinical manifestations result from an impaired step in the inflammatory process, namely, the emigration of leukocytes from the blood vessels to sites of infection, which requires adhesion of leukocytes to the endothelium. Over las...

It is well known that Arginine-Glycine-Aspartic acid (RGD) and Asparagine-Glycine-Arginine (NGR) peptides preferentially bind to integrin receptors and aminopeptidase Nrespectively and these two receptors play important roles in angiogenesis. Therefore ketoprofenas a non-selective cox Inhibitor was conjugated with linear RGD and NGR to take advantageof targeting capability of these two motifs a...

It is well known that Arginine-Glycine-Aspartic acid (RGD) and Asparagine-Glycine-Arginine (NGR) peptides preferentially bind to integrin receptors and aminopeptidase Nrespectively and these two receptors play important roles in angiogenesis. Therefore ketoprofenas a non-selective cox Inhibitor was conjugated with linear RGD and NGR to take advantageof targeting capability of these two motifs a...

Journal: :Journal of Materials Chemistry B 2021

Fibronectin coating increases implant biocompatibility by enhancing surface endothelializationviaintegrin-mediated binding.

Journal: :Journal of Cell Science 2021

ABSTRACT Integrin-mediated cell–extracellular matrix (ECM) interactions play crucial roles in a broad range of physiological and pathological processes. Kindlins are important positive regulators integrin activation. The FERM-domain-containing kindlin family comprises three members, kindlin-1, kindlin-2 kindlin-3 (also known as FERMT1, FERMT2 FERMT3), which share high sequence similarity (ident...

Journal: :MRS Advances 2021

Abstract Rapid migration of mesenchymal stem cells (MSCs) on device surfaces could support in vivo tissue integration and might facilitate vitro organoid formation. Here, polydopamine (PDA) is explored as a biofunctional coating to effectively promote MSC motility. It hypothesized that PDA stimulates fibronectin deposition this way enhances integrin-mediated capability. The random directional c...

Journal: :Advanced Healthcare Materials 2021

While much work has been done in the design of biomaterials to control integrin-mediated adhesion, less emphasis put on functionalization materials with cadherin ligands. Yet, cell–cell contacts combination cell–matrix interactions are key driving embryonic development, collective cell migration, epithelial mesenchymal transition, and cancer metastatic processes, among others. This review focus...

ژورنال: :کومش 0
نیوشا اسفندیاری یگانه newsha esfandiary yeganeh pharmaceutical sciences branch, islamic azad university, tehran iran1- دانشگاه آزاد اسلامی واحد علوم دارویی تهران نازنیک گالوستانیان nazenik galustanian pharmaceutical sciences branch, islamic azad university, tehran iran1- دانشگاه آزاد اسلامی واحد علوم دارویی تهران آیدا نصیرزاده گلجاهی aida nasirzadeh goljahi pharmaceutical sciences branch, islamic azad university, tehran iran1- دانشگاه آزاد اسلامی واحد علوم دارویی تهران مریم قدرتی maryam ghodrati skin research center- laboratory of protein and enzyme, shahid beheshti university (m.c), shohada-e tajrish hospital, tehran, iran2- دانشگاه علوم پزشکی شهید بهشتی، بیمارستان شهدای تجریش، مرکز تحقیقات پوست، آزمایشگاه پروتئین و آنزیم روبینا بغوزیان roobina boghozian dept. of immunology, faculty of medicine, tehran university of medical sciences, tehran, iran3- دانشگاه علوم پزشکی تهران، گروه ایمونولوژی الهام رسولی elham rasouli pharmaceutical sciences branch, islamic azad university, tehran iran1- دانشگاه آزاد اسلامی واحد علوم دارویی تهران الهام عباسی

سابقه و هدف: گزارش های مختلف بیان گر نقش آنتاگونیست های گیرنده آنژیوتانسین ii در مهار رشد تومورهای مختلف است. در چند مطالعه اخیر مشاهده شده که آنژیوتانسین ii می تواند بیان شدن برخی از فاکتورهای مهم در رشد تومورها را افزایش دهد. علاوه بر این نقش اینتگرین ها در رشد و متاستاز سلول های توموری مختلف اهمیت زیادی دارد ولی نقش آنژیوتانسین ii در میزان بیان شدن اینتگرین های سلول تومورال هنوز معلوم نیست. ...

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