We previously reported peritoneal innate-like integrin α4 (CD49d)highCD4+ T cells that provided help for B-1a cells. Here we analyzed the expression of various integrin chains on the peritoneal and pleural integrin α4highCD4+ T cells and investigated the functional heterogeneity of the subpopulations based on the integrin expression. Pleural cavity contained a lower ratio of integrin α4highCD4+...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Biegańska EA, Rokicki K, Karolewska-Bochenek Łazowska-Przeorek I, Banasiuk M. Anti-integrin treatment as an effective alternative for a patient with ulcerative colitis. Pediatria Polska - Polish Journal of Paediatrics. 2022;97(4):347-350. doi:10.5114/polp.2022.123917. APA Biegańska, E. A., Rokicki, K., Karolewska-...

Abstract CD157 is an ectoenzyme that has both cyclic ADP-ribose hydrolase and ADP-ribosyl cyclase activities. In the human hematopoietic system, prevalently expressed by cells of myelomonocytic lineage, interacts with extracellular matrix components regulates leukocyte diapedesis via integrin-mediated signaling. implicated in pathophysiology several neurological disorders. Although it lacks a c...

Nascent adhesions (NAs) are a general precursor to the formation of focal (FAs) that provide fundamental mechanism for cell adhesion is, in turn, involved proliferation, migration, and mechanotransduction. form when cells come into contact with substrates at all rigidities generally involve clustering ligated integrins may recruit un-ligated integrins. tend take on characteristic sizes range O(...

the hallmarks of leukocyte adhesion deficiency (lad) are defects in the leukocyte adhesion process, marked leukocytosis and recurrent infections. these molecular and clinical manifestations result from an impaired step in the inflammatory process, namely, the emigration of leukocytes from the blood vessels to sites of infection, which requires adhesion of leukocytes to the endothelium. over las...

The Effect of Silybinin on the Expression Vascular Endothelial Growth Factor (VEGF) and Integrin-linked kinase (ILK) in Olfactory Ensheathing Cells under Normal High Glucose Conditions

The integrin α4β7 selectively regulates lymphocyte trafficking and adhesion in the gut gut-associated lymphoid tissues (GALT). Here we describe unexpected involvement of tyrosine phosphatase Shp1 B cell lectin CD22 (Siglec 2) regulation surface expression immunity. inhibited β7 endocytosis, enhancing display homing to GALT. In cells, associated a sialic acid-dependent manner with on target intr...

Pathogenic variants in ITGB4 cause various forms of autosomal recessive epidermolysis bullosa (EB). encodes integrin-β4, which plays a critical role the maintenance skin basement membrane integrity. Here, we aimed to delineate genetic basis dominant isolated nail dystrophy 2 families. We studied total five affected individuals with and no other cutaneous or extra-cutaneous findings. Whole exome...

Mechanical tension is a critical determinant of cell growth, differentiation, apoptosis, migration, and development. Integrins have been implicated in sensing force but little is known about how forces are transduced to biochemical signals. We now show that mechanical strain stimulates conformational activation of integrin alphavbeta3 in NIH3T3 cells. Integrin activation is mediated by phosphoi...