نتایج جستجو برای: integrin

تعداد نتایج: 24065  

2017
Mark Boras Stephanie Volmering Arne Bokemeyer Jan Rossaint Helena Block Bernadette Bardel Veerle Van Marck Barbara Heitplatz Stefanie Kliche Annegret Reinhold Clifford Lowell Alexander Zarbock

Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The Src kinase-associated phosphoprotein 2 (Skap2) is involved in integrin functions in different leukocyte subtypes. However, the role of Skap2 i...

Journal: :Journal of cell science 2002
Birgit Leitinger Nancy Hogg

Integrin activity on cells such as T lymphocytes is tightly controlled. Here we demonstrate a key role for lipid rafts in regulating integrin function. Without stimulation integrin LFA-1 is excluded from lipid rafts, but following activation LFA-1 is mobilised to the lipid raft compartment. An LFA-1 construct from which the I domain has been deleted mimics activated integrin and is constitutive...

Journal: :The Journal of Cell Biology 2006
Aleksandra Czuchra Hannelore Meyer Kyle R. Legate Cord Brakebusch Reinhard Fässler

Akey feature of integrins is their ability to regulate the affinity for ligands, a process termed integrin activation. The final step in integrin activation is talin binding to the NPXY motif of the integrin beta cytoplasmic domains. Talin binding disrupts the salt bridge between the alpha/beta tails, leading to tail separation and integrin activation. We analyzed mice in which we mutated the t...

Journal: :The Journal of biological chemistry 2004
David A Calderwood Vera Tai Gilbert Di Paolo Pietro De Camilli Mark H Ginsberg

The ability of integrin adhesion receptors to undergo rapid changes in affinity for their extracellular ligands (integrin activation) is essential for the development and function of multicellular animals and is dependent on interactions between the integrin beta subunit-cytoplasmic tail and the cytoskeletal protein talin. Cross-talk among different integrins and between integrins and other rec...

Journal: :International journal of molecular medicine 2015
Long-Qiang Zhang Guang-Zong Zhao Xiao-Yan Xu Jun Fang Jing-Ming Chen Ji-Wen Li Xue-Jian Gao Li-Juan Hao Yun-Zhen Chen

Chondrocytes play a critical role in the repair process of osteoarthritis, which is also known as degenerative arthritis. Integrins, as the key family of cell surface receptors, are responsible for the regulation of chondrocyte proliferation, differentiation, survival and apoptosis through the recruitment and activation of downstream adaptor proteins. Moreover, G-protein-coupled receptor kinase...

2013
Mehrdad Mehrbod Mohammad R. K. Mofrad

Integrin clustering plays a pivotal role in a host of cell functions. Hetero-dimeric integrin adhesion receptors regulate cell migration, survival, and differentiation by communicating signals bidirectionally across the plasma membrane. Thus far, crystallographic structures of integrin components are solved only separately, and for some integrin types. Also, the sequence of interactions that le...

2011
Erik S Welf Ulhas P Naik Babatunde A Ogunnaike

BACKGROUND Regulation of integrin binding to the specific complementary sites on extra-cellular matrix (ECM) proteins plays a major role in cell adhesion and migration. In addition to regulating single integrin-ligand bonds by affinity modulation, cells regulate their adhesiveness by forming integrin clusters. Although it is clear that cells exhibit different adhesion and migration behaviors on...

2008
Jianming Liu Dean J. Burkin Stephen J. Kaufman

Liu J, Burkin DJ, Kaufman SJ. Increasing 7 1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression. Am J Physiol Cell Physiol 294: C627–C640, 2008. First published November 28, 2007; doi:10.1152/ajpcell.00329.2007.—The dystrophin-glycoprotein complex maintains the integrity of skeletal muscle by associating laminin in the extracellul...

Journal: :Applied sciences 2022

Osteoporosis is a complex bone disease indicating porous with low mass density and fragility. Cathepsin K, V-ATPase, αVβ3 integrin are exhibited as novel targets for osteoporosis treatment. Our preliminary study uses state-of-the-art method, including target-based virtual screening clustering methods to determine promising candidates multitarget properties. Phytochemicals osteoprotective proper...

Journal: :Revista Científica Hospital Santa Izabel 2021

SummaryBackground: Hair follicles are produced in a cyclical manner and the machinery involved reproduction of these is present since fetal stage. Although extensive research has been done on human hair follicle, very little known about importance adhesion molecules its development. Methods: We analyzed here, immunoexpression beta-1 integrin, p-cadherin, e- cadherin, beta-catenin from 26 formal...

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