نتایج جستجو برای: integrin

تعداد نتایج: 24065  

2004
Hironori Takatsuki Shinya Komatsu Rikio Sano Yoshikazu Takada Tsutomu Tsuji

The interaction between gastric carcinoma cells and the peritoneal lining is a key step in peritoneal dissemination. In this study, we examined the roles of the 1 family of integrin receptors in the adhesion of such cells to the peritoneum. The adhesion of several gastric carcinoma cell lines to peritonea excised from mice was inhibited most by an anti3 integrin antibody and to a lesser extent ...

Journal: :The Journal of Cell Biology 1989
R O Hynes E E Marcantonio M A Stepp L A Urry G H Yee

We report data showing that the integrin receptor complex in chickens contains several discrete heterodimers all sharing the beta 1-integrin subunit combined separately with different alpha-subunits. Using antisera to synthetic peptides based on cDNA sequences of chicken and human alpha-integrin subunits to analyze the integrin complement of avian and mammalian cells, we show that band 2 of the...

Journal: :The Journal of Cell Biology 1990
V M Belkin A M Belkin V E Koteliansky

A membrane glycoprotein complex was isolated and purified from human smooth muscle by detergent solubilization and affinity chromatography on collagen-Sepharose. The complex was identified as VLA-1 integrin and consisted of two subunits of 195 and 130 kD in SDS-PAGE. Liposomes containing the VLA-1 integrin adhered to surfaces coated with type I, II, III, and IV collagens, Clq subcomponent of th...

2014
Elizabeth M. Morse Nina N. Brahme David A. Calderwood

Integrins are heterodimeric cell surface adhesion receptors essential for multicellular life. They connect cells to the extracellular environment and transduce chemical and mechanical signals to and from the cell. Intracellular proteins that bind the integrin cytoplasmic tail regulate integrin engagement of extracellular ligands as well as integrin localization and trafficking. Cytoplasmic inte...

2011
Anja Mai Stefan Veltel Teijo Pellinen Artur Padzik Eleanor Coffey Varpu Marjomäki Johanna Ivaska

Integrin trafficking from and to the plasma membrane controls many aspects of cell behavior including cell motility, invasion, and cytokinesis. Recruitment of integrin cargo to the endocytic machinery is regulated by the small GTPase Rab21, but the detailed molecular mechanisms underlying integrin cargo recruitment are yet unknown. Here we identify an important role for p120RasGAP (RASA1) in th...

2015
Cheng-han Yu Nisha Bte Mohd Rafiq Fakun Cao Yuhuan Zhou Anitha Krishnasamy Kabir Hassan Biswas Andrea Ravasio Zhongwen Chen Yu-Hsiu Wang Keiko Kawauchi Gareth E Jones Michael P Sheetz

The turnover of integrin receptors is critical for cell migration and adhesion dynamics. Here we find that force development at integrins regulates adaptor protein recruitment and endocytosis. Using mobile RGD (Arg-Gly-Asp) ligands on supported lipid membranes (RGD membranes) and rigid RGD ligands on glass (RGD-glass), we find that matrix force-dependent integrin signals block endocytosis. Dab2...

Journal: :The Journal of Cell Biology 2002
R.C. Liddington M.H. Ginsberg

Integrins are cell surface adhesion receptors that are essential for the development and function of multicellular animals. Here we summarize recent findings on the regulation of integrin affinity for ligand (activation), one mechanism by which cells modulate integrin function. The focus is on the structural basis of integrin activation, the role of the cytoplasmic domain in integrin affinity r...

Journal: :International Journal of Molecular Sciences 2021

Chronic Kidney Disease (CKD) is associated with sustained inflammation and progressive fibrosis, changes that have been linked to altered connexin hemichannel-mediated release of adenosine triphosphate (ATP). fibrosis develops in response increased deposition extracellular matrix (ECM), up-regulation collagen I an early marker renal disease. With ECM remodeling known promote a loss epithelial s...

Journal: :Molecular medicine reports 2015
Zhuo Li Li Zhang Wei Shi Yuanhan Chen Hong Zhang Shuangxin Liu Xinling Liang Ting Ling Chunping Yu Zhongshun Huang Xiaofan Tan Xinchen Zhao Zhiming Ye Bin Zhang Wenjian Wang Ruizhao Li Jianchao Ma

Integrin β1 and β3 expression by podocytes is required to maintain glomerular structural integrity. Previous studies have shown that aldosterone (ALD) is involved in glomerular podocyte injury, and mineralocorticoid receptor (MR) blocker spironolactone effectively reduces proteinuria in patients with diabetic nephropathy. The present study was designed to observe the effects of spironolactone o...

2017
Maria Georgiadou Johanna Lilja Guillaume Jacquemet Camilo Guzmán Maria Rafaeva Charlotte Alibert Yan Yan Pranshu Sahgal Martina Lerche Jean-Baptiste Manneville Tomi P Mäkelä Johanna Ivaska

Tight regulation of integrin activity is paramount for dynamic cellular functions such as cell matrix adhesion and mechanotransduction. Integrin activation is achieved through intracellular interactions at the integrin cytoplasmic tails and through integrin-ligand binding. In this study, we identify the metabolic sensor AMP-activated protein kinase (AMPK) as a β1-integrin inhibitor in fibroblas...

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