BACKGROUND Autoantibodies against interferon-γ are associated with severe disseminated opportunistic infection, but their importance and prevalence are unknown. METHODS We enrolled 203 persons from sites in Thailand and Taiwan in five groups: 52 patients with disseminated, rapidly or slowly growing, nontuberculous mycobacterial infection (group 1); 45 patients with another opportunistic infec...

Benalu batu (B. medicinalis) is a plant endemic to Central Sulawesi that has been reported possess anticancer, antioxidant, and antiviral activities. The mechanism of action these activities still unclear. This study aimed evaluate the immunostimulatory effect ethanol extract B. medicinalis on an in vivo model by measuring macrophage phagocytotic activity cytokine production tumor necrosis fact...

The vast majority of Mycobacterium tuberculosis (M. tuberculosis) infected individuals are protected from developing tuberculosis and T cells are centrally involved in this process. MicroRNAs (miRNA) regulate T-cell functions and are biomarker candidates of disease susceptibility and treatment efficacy in M. tuberculosis infection. We determined the expression profile of 29 selected miRNAs in C...

Abstract T follicular helper (Tfh) cells comprise a subset of CD4 +T (Th) phenotypically and functionally distinct from Th1 Th2 cell subsets. Tfh are located within B follicles germinal centers (GC), where they secrete the cytokines IL-21 interferon-γ (IFN-γ) which aid in proliferation differentiation. CD9, tetraspanin, has been shown to accumulate on at immunological synapse, playing role co-s...

The time-sequential change in immune-related gene expression of the glioblastoma cell line after irradiation was evaluated to speculate effect combined immunotherapy with radiotherapy. U373 MG irradiated 6 Gy single dose. Next-generation sequencing (NGS) transcriptome data generated before (control), and at 6, 24, 48 h post-irradiation. Immune-related pathways were analyzed each time period. sa...

Objective(s): Breast cancer imposes a highest rate of malignancy among the women all around the world. Chitin and its derivatives such as D-glucosamine-carboxymethyl chitin and Di-hydroxy propyl chitin have immune-modulating effects and influence on innate and acquisitive immunity which lead to cell activity enhancement. The aim of this study was investigating the effect ...

Chlamydia trachomatis is one of the most common sexually transmitted bacterial pathogens in humans. The infection is often asymptomatic and can lead to chronic manifestations. The infectious elementary body and the replicating reticulate body are the two growth forms in the normal developmental cycle. Under the influence of interferon-γ, the normal cycle is disrupted because of tryptophan degra...

Bovine colostrum (BC) is a rich source of bioactive components reported to have health promoting effects. The purpose of the present study was to determine the effects of six-week supplementation of BC on the production of gamma-interferon (IFN-γ) by mitogen-stimulated peripheral blood leucocytes (PBL) in active adolescent male. Subjects were recruited from the students who were under-going reg...

BACKGROUND Interferon gamma (IFN-γ) production induces the transcription of indoleamine 2,3 dioxygenase (IDO) resulting in the reduction of T-cell activation and proliferation through the depletion of tryptophan and the elicitation of Treg lymphocytes. IDO was shown to be involved in the pathogenesis of autoimmune diseases; we investigated whether changes in IDO gene expression and activity cou...

PURPOSE Latent tuberculosis infection (LTBI) in young children may progress to severe active tuberculosis (TB) disease and serve as a reservoir for future transmission of TB disease. There are limited data on interferon-γ release assay (IGRA) performance in young children, which our research aims to address by investigating the usefulness of IGRA for the diagnosis of LTBI. METHODS We performe...