CD4+ T cells producing interferon-γ are crucial for protection against Mycobacterium tuberculosis infection and are the cornerstone of tuberculosis vaccination and immunological diagnostic assays. Since emerging evidence indicates that B cells can modulate T cell responses to M. tuberculosis infection, we investigated the contribution of B cells in regulating interferon-γ recall response by mem...

The eye is normally an immunosuppressive environment. This condition is better known as immune privilege and protects the eye from immune-mediated inflammation of tissues that cannot regenerate. However, immune privilege creates a dilemma for the eye when intraocular neoplasms arise. In some cases, immune privilege is suspended, resulting in the immune rejection of intraocular tumors. This stud...

background: interferon gamma (ifn-γ), a cytokine produced by a variety of cells is involved in the immune response against m. tuberculosis. it activates the production of other cytokines and molecules that kill mycobacterium. ifn-γ also has diagnostic role in identification of active and latent tuberculosis. objective: to determine the level of ifn-γ in the blood of tb patients. methods: ninety...

BACKGROUND: Interleukin-4 (IL-4) is a cytokine of Th2 response and plays role as reducer or silencer Th1 work. It more related to allergic processes, with consequent loss control the disease (i.e., tuberculosis). Interferon gamma (IFN-γ) Type II interferon that inhibits immune inducts inhibit tuberculous viral replication, any immunostimulatory immunomodulatory effects. Dark specks (DS) are in ...

Background: Several biological and medical benefits of Saffron, Crocus sativus (Iridaceae), have been demonstrated. However, mechanisms of actions for purified constituents are greatly unknown. Objective: To examine the effects of Safranal, a main constituent of Saffron stigma, on cell viability and cytokine profile of peripheral blood mononuclear cells (PBMC) were examined. Methods: Effect...

We developed an interferon-γ release assay (IGRA) specific for Asian elephants (Elephas maximus). Whole blood collected from forty captive Asian elephants was stimulated with three different mitogens i.e., phytohemagglutinin (PHA), pokweed mitogen (PWM) and phorbol myristate aceteate/ionomycin (PMA/I). A sandwich ELISA that was able to recognize the recombinant elephant interferon-γ (rEIFN-γ) a...

Cytokine-activated neutrophils are known to be essential for protection against group A Streptococcus infections. However, during severe invasive group A Streptococcus infections that are accompanied by neutropenia, it remains unclear which factors are protective against such infections, and which cell population is the source of them. Here we show that mice infected with severe invasive group ...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 objectives: there is an association between viral infection and development of diabetes mellitus. this study aimed to investigate the role of rubella virus, cytomegalovirus and coxsackievirus in patients with type 1 (t1d)and type 2 (t2d) diabetes mellitus in respect to the glycemic control and immune response presented by ...

interferon- gamma (ifn- γ) is an important immune regulator and inflammatory cytokine which is implicated in the pathogenesis of multiple sclerosis (ms). a single nucleotide polymorphism, t to a, at position +874 in the first intron has previously been shown. this polymorphism is associated with ifn- γ production level. to study the effect of this polymorphism on susceptibility to multiple scle...