The proliferative response of fresh peripheral blood loukemic cells from eight adult T cell leukemia (ATL) patients to interleukin-4 (11-4) was studied to determine the possibility that the 11-4-mediated T-ceIl growth pathway is involved in the cell growth of leukemic cells in ATL. Resting lymphocytes from ten normal individuals did not proliferate in response to ll-4. Leukemic cells from two A...

conclusions increased serum levels of interleukins 6 and 8 as a predictive marker might be associated with unfavorable clinical outcome in patients with severe tbi. results comparing the serum levels of interleukins in two groups with favorable and unfavorable clinical outcomes showed that the mean serum levels of interleukins 6 and 8 in group with favorable outcome was 85.2 ± 51.6 and 52.2 ± 3...

The cytokine interleukin (IL)-11 has been shown to play a role in promoting fibrosis and cancer, including lung adenocarcinoma, garnering interest as an attractive target for therapeutic intervention. We used combinatorial methods engineer IL-11 variant that binds with higher affinity the receptor stimulates enhanced receptor-mediated cell signaling. Introduction of two additional point mutatio...