The cellular basis of immunological memory remains a controversial issue. Here we show that basophils bound large amounts of intact antigens on their surface and were the main source of interleukins 6 and 4 in the spleen and bone marrow after restimulation with a soluble antigen. Depletion of basophils resulted in a much lower humoral memory response and greater susceptibility of immunized mice...

Introduction. Inflammation is ubiquitous during sepsis and may be influenced by body mass index (BMI). We sought to evaluate if BMI was associated with serum levels of several cytokines measured at intensive care unit admission due to sepsis. Methods. 33 septic patients were included. An array of thirty-two cytokines and chemokines was measured using Milliplex technology. We assessed the associ...

background:  levels of anti-inflammatory cytokines in blood have a positive relationship with congenital heart disease (chd). we sought to assess the difference in serum cytokines levels between children with and without chd.  methods:  we recruited 60 patients with chd and 30 healthy children, from 2013 to 2014. patients with primary pulmonary hypertension; metabolic diseases; renal, endocrine...

background: the role of mesenchymal stem cell in cellular therapy is the subject of interest for many researchers. the differentiation potential of mscs and abilities in modulations of the recipient’s immune system makes them important cells in tissue regenerative studies. mscs by releasing the proinflammatory cytokines play important role in immunomodulatory systems; however the signaling path...

Background: Polycystic ovary syndrome (PCOS) stands for highly prevalent female endocrine pathology. Females suffering from PCOS have a significantly higher number of inflammatory markers. The IL-1 family members enormously affect the innate immune system. Objectives: Study changes in levels Interleukin- 1ß and 27 stimulated non-stimulated cycle (by gonadotrophin) polycystic ovarian women. Meth...

background: multiple sclerosis (ms) is known as a progressive central nervous system inflammatory disease. certain factors, such as interleukins, inflammatory cells, and oxidative stress are supposed to involve in ms etiology. because of the important role of oxidative stress, antioxidant therapy for ms has received more attention. although coenzyme q10 (coq10) acts as an antioxidant, there is ...

Background: Multiple sclerosis (MS) is known as a progressive central nervous system inflammatory disease. Certain factors, such as interleukins, inflammatory cells, and oxidative stress are supposed to involve in MS etiology. Because of the important role of oxidative stress, antioxidant therapy for MS has received more attention. Although coenzyme Q10 (CoQ10) acts as an antioxidant, there is ...