Type 2 diabetes mellitus (T2D) is a significant global public health problem that has seen substantial increase in the number of affected individuals recent decades. In murine model T2D (db/db), we found several abnormalities, including aberrant intracellular calcium concentration ([Ca2+]i), decreased glucose transport, increased production reactive oxygen species (ROS), elevated levels pro-inf...

Our data show that botulinum toxin A (BoNT/A) didn't influence motor functions in naïve and CCI-exposed rats, but diminished the neuropathic pain-related behavior. The results indicate that BoNT/A administration diminished the spinal Iba-1 positive cells activation and, in parallel, downregulated IL-1beta. Moreover, we observed that in DRG the protein level of pronociceptive factors (IL-1beta a...

BACKGROUND More and more studies have suggested that single-nucleotide polymorphisms (SNPs) in interleukin (IL) genes are correlated with an increased risk of developing oral lichen planus (OLP). However, these results were inconsistent. Therefore, the aim of this meta-analysis is to retrieve and comprehensively analyze all related clinical studies to investigate the association of ILs gene pol...

Background Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology that can affect various organ systems, particularly the kidneys [1] . Interleukin-6 (IL-6), Interleukin-17 (IL-17), and tumour necrosis factor-α (TNF-α) are closely correlated with risk SLE play a significant role in pathogenesis disease. However, causal relationship between these cytokines has not been e...