The interleukin-2 molecule and receptor were the first of the interleukins to be discovered and characterized at the molecular level. Now after 20 years of effort, two groups have succeeded in determining the structure of IL2 bound to the external domains of the three receptor chains in a quaternary complex. What do we know now that we did not know before this structural information was availab...

(1844 articles) Transplantation • (1930 articles) Signal Transduction • (4939 articles) Immunobiology • (564 articles) Chemokines, Cytokines, and Interleukins • Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be...

In addition to the role that cytokines (growth factors, interleukins, instructive factors) play in regulating neuronal survival, growth and gene expression during development, recent evidence suggests that these intercellular signals can also control similar functions in the normal, as well as the injured, adult nervous system. Some of this evidence is summarized here, with particular emphasis ...

(973 articles) Phagocytes • (564 articles) Chemokines, Cytokines, and Interleukins • (790 articles) Cell Adhesion and Motility • Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjou...

Mycophenolate mofetil (MMF) is a pro-drug of the active metabolite of mycophenolic acid. It is a suppressor of T and B cell proliferation and adhesion and inhibits inosine monophosphate dehydrogenase that eventually blocks the progression to DNA synthesis and proliferation [1]. It does not inhibit the production of interleukins as does ciclosporin and tacrolimus. MMF has routinely been used in ...

The role of inflammatory cytokines in the pathophysiology of beta-thalassaemia is still unclear. In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells-from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. ...

(3094 articles) Hematopoiesis and Stem Cells • (564 articles) Chemokines, Cytokines, and Interleukins • (790 articles) Cell Adhesion and Motility • Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online ...

Unfortunately, a normal (or negative) concentration of parathyroid hormone related protein (PTHrP) does not rule out the presence of malignancy. PTHrP is only one of a number of factors that tumors may secrete that can result in an elevated calcium concentration (e.g. interleukins, tumor necrosis factor, etc.). Thus even if the PTHrP concentration is within normal limits, malignancy may still b...

Exercise; heart failure; coronary artery disease; interleukins. Anti-inflammatory Effect of Physical Training in Heart Failure: Role of TNF-α and IL-10 Miguel Luiz Batista Júnior1, Renato Delascio Lopes2,3, Marília Cerqueira Leite Seelaender1, Antonio Carlos Lopes2 Grupo de Biologia Molecular da Célula Instituto de Ciências Biomédicas I e Departamento de Medicina Interna Universidade Federal de...