Epidermal growth factor receptor inhibitors(EGFRi) and Mitogen Activated Kinase inhibitors(MEKi) induce a folliculitis in 65-80% of patients, but it is unclear how they impact on the human hair follicle(HF). We have asked whether EGFRi/MEKi-induced associated with damage HFs immune privilege(IP) excessive HF secretion pro-inflammatory mediators. Scalp biopsies were taken from EGFRi-treated pati...

Hexavalent chromium (CrVI) is a heavy metal widely used in more than 50 industries. Nephrotoxicity is a major adverse effect of chromium poisoning. The present study investigated the potential renoprotective effect of lactoferrin (Lf) against potassium dichromate (PDC)-induced acute kidney injury (AKI) in rats. Beside, because previous studies suggest that interlukin-18 (IL-18) and insulin-like...

Background: Interleukin-17 (IL-17), as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. However, there is not much information about the effects of IL-17 cytokine on acute liver rejection. Objective: To evaluate the role of IL-17 in post-liver transplant acute rejection. Methods: Ninety seven adult liver transplant patients who enrolled in this cross sec...

background: in fertility studies, it has been shown that transforming growth factor β (tgfβ) and interlukin 10 (il-10) play very important roles in implantation, maternal immune tolerance, placentation and fetal development, and the release beginning of release for fetal and postnatal death. the present study aims to determine the effects of the postmating administration of neutralizing antibod...

introduction: human t cell lymphotropic l.irus type i is responsible for adult t cell leukemia/lymphoma and htlv-i associated myelopathy. the aim of this study was constructing two reporter plasmids to enable us to evaluate the effects of htlv-i tax protein upon intra cellular signalling pathways which recruit creb and nfkb proteins. material and methods: a complete coding region of bacterial b...

introduction: umbilical cord blood (cb) has been identified as a rich source for hematopoietic stem cells (hscs), and has provided an alternative to bone marrow transplantation. the use of ex vivo expanded cells has been suggested as a possible means to accelerate the speed of engraftment in cord blood (cb) transplantation. the main aim of our study is to find the best culture media and conditi...