INTRODUCTIION: Interlukin-7 (IL-7) is expressed in osteoarthritis fibroblast-like synoviocytes (hTERT-OA 13A FLS) 8 fold higher than that in rheumatoid FLS (hTERT-RA 516 FLS) (1). Major histocompatibility complex class II protein DP alpha 1 (HLA-DPA1) is also highly expressed in hTERT-OA 13A FLS. Recently, it has been found that IL-7 and its receptor IL-7R are expressed in OA articular chondroc...

Background: Airway epithelial cells may play an important clinical role in the apoptosis of eosinophils. To study recognition pathways, two types of large bronchial airway epithelial cells were used (LAECs and A549). Methods: Both resting, and dexamethasone-stimulated epithelial cells, were used in an inhibition assay. Confocal microscopy was used to demonstrate engulfment of apoptotic eosinoph...

involved in Toll-like receptors. However, there has been no reported association between receptor-interacting serine/threonine kinase 2 (RIPK 2) expression and the infectious diseases involving mycobacterial infection. This study found that its expression was down-regulated in the footpads and skin but was upregulated in the liver of Mycobacterium leprae infected nu/nu mice compared with those ...

Latar belakang: COVID-19 menjadi masalah kesehatan di dunia. Penanda inflamasi yang dapat digunakan sebagai predictor prognosis salah satunya Interlukin-6 (IL-6) dan Neutrofil Lymphocyte Ratio (NLR). Tujuan penelitian: mengetahui hubungan kadar IL-6 dengan NLR pada pasien COVID-19. Metode: Penelitian kuantitatif desain cross sectional. Data dikumpulkan dari rekam medik RS Kanker Dharmais period...

RIPK 2 is adapter molecule in the signal pathway involved in Toll-like receptors. However, there has been no reported association between receptor-interacting serine/threonine kinase 2 (RIPK 2) expression and the infectious diseases involving mycobacterial infection. This study found that its expression was down-regulated in the footpads and skin but was up-regulated in the liver of Mycobacteri...

Zerumbone is a sesquiterpene present in Zinger zerumbet. Many studies have demonstrated its marked anti-inflammatory and anti-carcinogenesis activities. Recently, we showed that zerumbone binds to numerous proteins with scant selectivity and induces the expression of heat shock proteins (HSPs) in hepatocytes. To dampen proteo-toxic stress, organisms have a stress-responsive molecular machinery,...

OBJECTIVE Annexin A1 (ANXA1) is suggested to have anti-inflammatory function. However, the precise function of ANXA1 has remained unclear. In this study, we therefore examined the potency of ANXA1 in regulating reactive oxygen species (ROS) production and suppressing pro-inflammatory responses in PC12 cells induced by 1-methyl-4-phenylpyridinium (MPP+). MATERIALS AND METHODS In this experimen...

Suhuang antitussive capsule (Suhuang), a traditional Chinese medication, is found effective in treating chronic cough and cough variant asthma (CVA). This study aimed to determine the possible effects and underlying mechanisms of Suhuang on chronic ovalbumin (OVA)-induced airway hyperresponsiveness (AHR), inflammation, and remodeling in mice. Mice were randomly assigned to six experimental grou...

A study was made to observe the association between the resistance to reinfection induced by irradiated metacercariae (MC) of Clonorchis sinensis and antigen specific Th1- and Th2-type cytokine productions in rats. Rats were infected with 20 MC of C. sinensis, previously exposed to a single dose of gamma irradiation, which varied from 0 to 100 Gy. All of them, single dose of 12 Gy showed higher...