Chromosomes can be specifically stained in metaphase spreads and interphase nuclei by in situ hybridization with entire chromosome-specific DNA libraries. Unlabeled human genomic DNA is used to inhibit the hybridization of sequences in the library that bind to multiple chromosomes. The target chromosome can be made at least 20 times brighter per unit length than the others. Trisomy 21 and trans...

Development of high-performing lithium-based batteries inevitably calls for a profound understanding and elucidation the reactivity at electrode–liquid electrolyte interface its impact on overall performance safety. The formation, composition, properties, mechanisms cathode interphase (CEI) formation function are still to large extent unknown most battery materials, whereas same is well conside...

The metal/hydrogen system is a key element in the construction of ecologically preferred energyconversion/storage devices. Although reduced to practice decades ago, its effectiveness requires fur-ther examination of a number of issues, among them the role that the electrode/electrolyte interphaseplays during the charging/discharging processes. In this communication the following...

I. 3D organization of the chromatin in the interphase nucleus 1. Relationship of the chromatin with the nucleus structures 2. Notion of chromosomal territories 3. Topography of the territories 4. Interface between neighbor territories 5. Organization model of the chromatin in the interphase nucleus II. Relative evolution of the territories when compared to each other during the succession of th...

Tetrahedrally close-packed structures with juxtaposed pentagonal antiprisms, such as the F, C14 Laves and the newly found C phases, were studied by means of HREM and SAD. It was found that each bright spot in the structural image corresponds to an antiprism. Differently oriented domains of these phases intergrow frequently with a fairly good match at the interphase boundary. All diffraction pat...

Higher-order chromatin fibers (200--300 A in diameter) are reproducibly released from nuclei after lysis in the absence of formalin and/or detergent. Electron microscope analysis of these fibers shows that they are composed of a continuous array of closely apposed nucleosomes which display several distinct packing patterns. Analysis of the organization of nucleosomes within these arrays and the...