Idiopathic calcification of the intervertebral disc is a rare condition in childhood, of unknown etiology. Calcifications are occasionally discovered on routine radiological examination, or on investigation of nonspecific symptoms such as neck pain, torticollis, fever, and radiculopathy. We report a case of a 7-year-old boy with intervertebral disc calcification. Clinical and radiological signs...

Intervertebral disc degeneration (IDD) is a common orthopedic disease associated with mechanical changes that may result in significant pain. Current treatments for IDD mainly depend on conservative therapies and spinal surgeries that are only able to relieve the symptoms but do not address the cause of the degeneration and even accelerate the degeneration of adjacent segments. This has prompte...

Background & Aim: Low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. Although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration. Present therapies for Intervertebral Disc (IVD) degeneration such as physical therapy and spinal fusion reduce symptoms' severity, but do not treat the ...

Intradural disc herniation is a rare entity that occurs most commonly in the lumbar spine particularly at L4-L5 region. Most often it is diagnosed intraoperatively in a case of simple intervertebral disc herniation. Contrast enhanced MRI is mandatory for pre operative diagnosis. We describe a case of a 40-year-old female who presented to us with pain lower back, pain in both lower limbs and uri...

INTRODUCTION Degeneration of the intervertebral discs cause discogenic low back pain and limited mobility. Current surgical treatments include spine fusion, which eliminates pain but does not restore disc function, or implantation of synthetic disc prostheses. However, these materials face challenges in fixation, mechanical strength and loosing of the implant [1]. Tissue engineering strategies ...

Low back pain, which is often caused by disc degeneration, is a major health problem. Due to the limitations of the current treatments for degenerative disc disease, tissue engineering methods have been proposed. These methods present the opportunity to restore the functionality of the intervertebral disc by repairing or replacing the degenerated tissue. One of the major challenges in intervert...

Approximately 2.6 % of the US population visits a physician for treatment of spinal disorders annually (Fraser 2009 ) with costs of $7.1 billion from lost work days alone (Ricci et al. 2006 ) . “Herniation” of the intervertebral disc is one of the several spinal disorders that contribute to this very high incidence, with potential to cause signi fi cant pain, neurological de fi cit, and functio...

Degeneration of the lumbar intervertebral discs is irreversible, with no treatment currently available. Building upon experimental studies that demonstrated the importance of the nucleus pulposus (NP) in preserving disc structure, we demonstrated that reinsertion of NP cells slowed further disc degeneration and that direct cell-to-cell contact co-culture with mesenchymal stromal cells (MSCs) si...

STUDY DESIGN Descriptive, microdissection study. OBJECTIVE To determine the morphology of the human adult cervical intervertebral disc and its ligaments. SUMMARY OF BACKGROUND DATA Some studies indicate that the cervical disc is distinctly different from the lumbar intervertebral disc, yet most clinical and anatomic texts appear content with extrapolating data from the lumbar spine. A detai...