STUDY DESIGN Investigation of the effects of the impairment of different nutritional pathways on the intervertebral disc degeneration patterns in terms of spatial distributions of cell density, glycosaminoglycan content, and water content. OBJECTIVE The aim of this study was to test the hypothesis that impairment of different nutritional pathways would result in different degenerative pattern...

Disc degeneration is a multifactorial process that involves hypoxia, inflammation, neoinnervation, accelerated catabolism, and reduction in water and glycosaminoglycan content. Cannabidiol is the main non-psychotropic component of the Cannabis sativa with protective and anti-inflammatory properties. However, possible therapeutic effects of cannabidiol on intervertebral disc degeneration have no...

This study was to evaluate the effect of stress on the intervertebral disc and facet joint after implantation of device for intervertebral assisted motion (DIAM). Nine fresh human lumbar (L1-L5) cadavers were studied. The stress on L3-4, adjacent intervertebral disc and facet joints was measured in four groups. The cadavers in Group 1 were measured without special treatment; the lumbar discecto...

BACKGROUND Recent evidence suggests that estrogens exert effects in different tissues throughout the body, and that the estrogen receptor beta (ERbeta) may be important for the action of estrogen (17-beta-estradiol) on the skeleton. The cellular localization of ERbeta in the human intervertebral disc, however, has not yet been explored. METHODS Human disc tissue and cultured human disc cells ...

BACKGROUND: Fenestration is a simple, superior and economic operation than laminectomy microdiscectomy and percutaneous discectomy, which require costly & sophisticated set ups. Fenestration provided the excellent results comparable to laminectomy procedure, and at the same time preserved the spinal stability and provided the early mobility & early return to previous job. To analyses the result...

INTRODUCTION Low back pain is a major economical and social problem nowadays. Intervertebral disc herniation and central degeneration of disc are two major reasons of low back pain that occur because of structural impairment of disc. The intervertebral disc contains three parts as follows : Annulus fibrosus, transitional region, and nucleus pulposus, which forms the central nucleus of the disc....

It is the unique interaction between the solid and fluid components that provide the intervertebral discs the strength and flexibility necessary to bear the physiological loading of the spine. The current research is directed towards developing a numerical model of a lumbar disc including the fluid flow into and out of the intervertebral disc. The presence of the fluid is imperative in order to...

Dogs presented to the Small Animal Hospital of Veterinary Medicine, University of Tehran were included in the present study if spinal or intervertebral disc involvement was suspected. Clinical signs were recorded as well as general information of the patient such as age, breed and sex. Sixty dogs were examined radiographically and two standard orthogonal lateral and ventrodorsal projections wer...

BACKGROUND Magnetic resonance imaging (MRI) studies have shown that gymnasts have a high prevalence of radiological abnormalities, such as intervertebral disk degeneration (IDD) and anterior limbus vertebra (ALV). These 2 abnormalities may coexist at the same spinal level. However, the relationship between IDD and ALV remains unclear. HYPOTHESIS A significant relationship exists between IDD a...

The inter-lamellar connectivity of the annulus fibrosus in the intervertebral disc has been shown to affect the prediction of the overall disc behaviour in computational models. Using a combined experimental and computational approach, the inter-lamellar mechanical behaviour of the disc annulus was investigated under conditions of radial loading. Twenty-seven specimens of anterior annulus fibro...