Intervertebral disc degeneration is a primary cause of low back pain and has a high societal cost. The pathological mechanism by which the intervertebral disc degenerates is largely unknown. Cell-based therapy especially using bone marrow mesenchymal stem cells as seeds for transplantation, although still in its infancy, is proving to be a promising, realistic approach to intervertebral disc re...

BACKGROUND Canine intervertebral disc degeneration can lead to intervertebral disc disease. Mild degenerative changes in the structure of the canine intervertebral disc can be identified in magnetic resonance images, whereas these changes are not visible in computed tomographic images. Therefore, one aim of this study was to detect whether colour-coded computed tomography enhances the visibilit...

The goal of the study is to show the histological and biochemical changes that indicate the angiogenesis of the intervertebral disc in lumbar intervertebral disc hernia and the existence of epidemiological correlations between these changes and the risk factors of lumbar intervertebral disc hernia, as well as the patient's quality of life (QOL). We have studied 50 patients aged between 18 and 7...

background: spine of an adult is made up of five areas that include 7 cervical vertebrae, 12 thoracic vertebrae, 5 lumbar vertebrae, sacrum and finally coccyx. selecting appropriate assumptions for modeling and biological analysis of the spine components has a significant impact on the accuracy of results in biomechanical simulation for different modes. methods: in the present study, biomechani...

STUDY DESIGN An in vitro biomechanical investigation in the human lumbar spine focuses on the functional significance of vertebral bone density and intervertebral disc degenerations. OBJECTIVE To determine that interrelationship between vertebral bone density and intervertebral disc degeneration, their effect on normal spine motion, and their significance in the biotechnical performance of in...

Low back pain secondary to degenerative intervertebral disc disease contributes to significant pain and disability in the United States. The potential to reverse intervertebral disc degeneration has driven significant interest in the development of stem cell therapy for degenerative disc disease. Early animal models have demonstrated that stem cell therapy may facilitate the reversal of the dis...

OBJECTIVE To evaluate the correlation between the severity of intervertebral disc injury and the anteroposterior type of thoracolumbar vertebral fractures. METHODS Fifty-six cases of thoracolumbar vertebral fractures treated in our trauma center from October 2012 to October 2013 were included in this study. The fractures were classified by the anteroposterior classification, whereas the sever...

Thoracolumbar intervertebral disc disease is the most common cause of caudal paresis in dogs. Whilst the pathogenesis of the extrusion has been widely studied, treatment protocols and prognostic factors relating to outcome remain controversial. Recent studies have examined a multitude of factors relating to time to regain ambulation after decompressive surgery. Most intervertebral disc herniati...

Although human intervertebral disc degeneration can lead to several spinal diseases, its pathogenesis remains unclear. This study aimed to create a new histological classification applicable to an in vivo mouse intervertebral disc degeneration model induced by needle puncture. One hundred six mice were operated and the L4/5 intervertebral disc was punctured with a 35- or 33-gauge needle. Micro-...

Intervertebral disc degenerative diseases have become a serious social health problem. However, there is no clinical treatment effectively retarding the progression of intervertebral disc degeneration. Crocin, which is extracted from saffron, has been proved to exert anti-inflammatory and anti-catabolic effects on intervertebral disc in vitro and ex vivo. In the present study, effects of crocin...