Direct measurements of arterial blood pressure and intracranial pressure were recorded in 39 patients aged 3.6 months to 5 years 11 months with Reye's syndrome judged to be stage 2 or beyond. Of 33 patients who survived, 27 made a full recovery and six were severely handicapped. Measurement of cerebral perfusion pressure, which is greatly reduced in the more severe forms of Reye's syndrome, was...

Applied Physics Laboratory, University of Washington, Seattle, WA 98195 Department of Statistics, University of Washington, Seattle, WA 98195 Department of Neurological Surgery, University of Washington, Seattle, WA 98195 Department of Neurosurgery, University of Cambridge, Box 167, Addenbrooke’s Hospital, Cambridge, CB20QQ, United Kingdom Department of Bioengineering, University of Washington,...

OBJECTIVE To determine adherence to Brain Trauma Foundation guidelines for intracranial pressure monitoring after severe traumatic brain injury, to investigate if characteristics of patients treated according to guidelines (ICP+) differ from those who were not (ICP-), and whether guideline compliance is related to 6-month outcome. DESIGN Observational multicenter study. PATIENTS Consecutive...

The causes of death and neurological sequelae in African children with cerebral malaria are obscure. Intracranial pressure (ICP) was monitored and cerebral perfusion pressure (CPP) calculated in 23 Kenyan children with cerebral malaria. Four children had severe intracranial hypertension (ICP > 40 mm Hg, CPP < 40 mm Hg): two died, one with an ICP of 158 mm Hg and signs of transtentorial herniati...